Little evidence that serotonin imbalance causes depression

https://www.theguardian.com/society/2022/jul/20/scientists-question-widespread-use-of-antidepressants-after-survey-on-serotonin

Excuse me, what the fuck? Am I reading this correctly? How did they get away with this shit?

  1. 4 weeks ago
    Anonymous

    This is the result of treating the symptoms instead of the cause. The world is in a bad place atm especially with social media frying zoomer brains so they can never feel like they have meaning.

    • 4 weeks ago
      Anonymous

      yeah no shit, its because some people have too many SERT transporters that remove serotonin from the synaptic cleft too fast. also 95% of your serotonin is not in your brain. nice headline reading OP. moronbrain

      • 4 weeks ago
        Anonymous

        cope, pillcuck

    • 4 weeks ago
      Anonymous

      I've really wondered this, because it seems like the people who are depressed have actual reasons why they'd be depressed and just giving them drugs isn't going to help that shit necessarily

  2. 4 weeks ago
    Anonymous

    >theguardian

    • 4 weeks ago
      Anonymous

      Yet another example of Ray Peat being right.
      >pufa
      >body temperatures
      >sugar vs starch
      >red light
      >pigs in sweaters
      >pregnenolone

      Then post the proof. Not some random pubmed correlation study, but an actual, pear reviewed piece of proof posted on Nature or something equivalent.

      • 4 weeks ago
        Anonymous

        >pufa
        >body temperatures
        >sugar vs starch
        >red light
        >pigs in sweaters
        >pregnenolone
        Elaborate

      • 4 weeks ago
        Anonymous

        Oh I’m not looking for shit. I don’t even take antidepressants. For you to post an article from one of the most biased and shameless news articles in the world is proof of your insanity though.

      • 4 weeks ago
        Anonymous

        >pufa
        >body temperatures
        >sugar vs starch
        >red light
        >pigs in sweaters
        >pregnenolone

        Seconding the other guy. Explain what you're on about.

        https://i.imgur.com/egA9ZoO.png

        This.
        Mental diseases are generally a gut disease, where the body gets overloaded by inflamation and this affects the brain

        Cool helmet. What is it from?

        • 4 weeks ago
          Anonymous

          Ray Peat is right, literally Google “ray peat <topic>”

          Pigs in sweaters have more saturated fat

        • 4 weeks ago
          Anonymous

          I think the helmet is just some design by some japanese guy. Bought it here.

          https://www.hypebrother.com/product-cyberpunk-mask.html

      • 4 weeks ago
        Anonymous

        >pear reviewed

      • 4 weeks ago
        Anonymous

        >posts word salad
        >refuse to elaborate
        >leaves
        based schizofag

      • 4 weeks ago
        Anonymous

        There is a very simple proof why anyone who advocates for any specific diet as the "ultimate/best" diet is completely wrong.
        https://en.wikipedia.org/wiki/Nutritional_genomics

        As a personal example, Ray Peat is completely off base for me specifically as any form of sugars are extremely bad for my gut. They give me epic diarrhoea even in small quantities. This includes basically all fruits except for small quantities of berries. It includes honey, sugar, carrots, etc.

        Diet is very personal, because of genetics. The best thing you can do is find what works well for you, what foods your body tolerates, and which it does not, and to focus on those that it tolerates.

        Even the paleo people are morons, because there are people who are unable to handle large quantities of fat.

        Every diet that claims to be the perfect diet for all people is a bunch of bullshit.

        And every person who believes in such a thing is a low IQ moron.

      • 4 weeks ago
        Anonymous

        >Then post the proof.
        There wasn't proof that serotonin imbalance causes depression in the first place. You just bought the hype from "experts," and think you understand everything. Love it when Big Pharma dicks people over.

  3. 4 weeks ago
    Anonymous

    SSRIs desensitize 5ht1a autoreceptors, which are a shut-of valve for serotonin release. This cascades into releasing BDNF as well, increases the size of the ventral dendats gyrus among others, implicated in anxiety & stress tolerance. We are pretty sure of how & why they work.

  4. 4 weeks ago
    Anonymous

    Obviously prescription antidepressants are over prescribed. I do believe there are some people whose brains literally do not work without medical intervention. Once dated a BPD girl and if she had an untreated depressive episode it was truly devastating.

    However, majority of “depression” can be cured via:
    >sleep
    >sun
    >exercise
    >whole foods
    >social activity

    It is shocking and unforgivable that physicians will prescribe hardcore antidepressants without requiring lifestyle changes.

    • 4 weeks ago
      Anonymous

      This.
      Mental diseases are generally a gut disease, where the body gets overloaded by inflamation and this affects the brain

      • 4 weeks ago
        Anonymous

        How the fuck am I supposed to hit calories eating nothing but organic meat and bone broth? Please respond I’m mentally ill

        • 4 weeks ago
          Anonymous

          Assuming that you are mentally ill, you will have to see the first stages of the GAPS diet as a fast in which you are allowed to drink broth. Hitting calories are not important. Then as you slowly ad more food, you can start to increase your calorie intake.

          Imagine what gains you will make once your gut is healed and you can digest all the macros and micros. I might do this for this particular reason.

          • 4 weeks ago
            Anonymous

            GAPS + oral bpc-157=?
            surely you could take this approach and cut the healing time down to like a month

      • 4 weeks ago
        Anonymous

        I really liked your video anon. Great backdrop, quick and easy information, you have a nice voice and speak English very well.

        • 4 weeks ago
          Anonymous

          Thanks!

      • 4 weeks ago
        Anonymous

        Subscribed bro.. do you have any book recommendations I can read about this?

        • 4 weeks ago
          Anonymous

          Yes pic related, the yellow book is about mental health, you can also read her blue book. That can be a bit more IST related since it is about how the gut works and how to cure digestive issues, so that you can absorb nutrients better (for the gains).

    • 4 weeks ago
      Anonymous

      Prescription happens usually when a normal therapy is not working or impossible to establish

      • 4 weeks ago
        Anonymous

        The therapy is not an effective form of treatment either way. Depression is a disease of the body and mind. If someone's body is not healthy their mind cannot be healthy. Also, therapists treatment measures vary so much you're going to get the same results from seeing a zen Buddhist or priest, and they're not permanent results.

        • 4 weeks ago
          Anonymous

          Wrong, cognitive behavioral therapy works very well and long lasting, granted we're just figuring out but therapies improved with time

          • 4 weeks ago
            Anonymous

            Yes, but you don't need a therapist to change thinking patterns. Thinking patterns are like learning to punch incorrectly. The more you do an action the more it becomes engrained, but you can still change it through drilling the proper technique.

      • 4 weeks ago
        Anonymous

        Bullshit, I got whacked on these when I was 18 without any attempt at therapy. Weaned myself off around 22, tried to get therapy at 24 - was told I had to be prescribed drugs to get the therapy. Fortunately I was smart enough that time to not take them.

        • 4 weeks ago
          Anonymous

          It's all a big racket. My friend is a therapist and he's a total wreck anyways. He's fun to go drinking with but the idea of taking his advice is ludicrous.

      • 4 weeks ago
        Anonymous

        Absolutely not true, you have no idea what you're talking about. SSRIs are prescribed first even if you don't do therapy

      • 4 weeks ago
        Anonymous

        You can get Wellbutrin and Lexapro by filling out a survey monkey and chatting with a doctor for three minutes https://www.forhims.com/psychiatry

      • 4 weeks ago
        Anonymous

        You're wrong, it's not debatable.
        I have seen SSRIs prescribed day 1 to dozens of people. They hand them out like candy.
        >oh you're depressed here is lexapro or welbutrin 5 mg we will bump it up in a month
        almost half of all women are on SSRIs and wonder why they are fucking sad all the time.

        • 4 weeks ago
          Anonymous

          This.
          SSRIs seem to form a physical and emotional dependency, where most people who got on them were just going through a low phase and didn't need them to begin with.
          This society falls for quick band-aid fixes over putting in hard work and suffering even the tiniest bit.
          Because "trust the science [blindly]" is such a meme these days, people have stopped thinking for themselves; and have stopped taking counsel from family and friends to instead get it from some person/people they don't know and could care less about them - especially true with women.

        • 4 weeks ago
          Anonymous

          In all fairness if I was a woman I’d be fucking miserable. I get it

  5. 4 weeks ago
    Anonymous

    Because research in psychology was funded by drug companies wishing to push prescriptions. They have literally never measured chemicals in the brain and the whole "it's just chemicals" can't account for any psychological disorder.

    You'd think with schizophrenia you'd measure a patient's brain chemicals, but no, they basically just give them a drug that calms them. It's not a drug to try to balance anything, it's just a drug to sedate them through psychosis. Same with depression, the serotonin inhibitors do not treat depression, they sedate you. You can cure depression through exercise, diet, and changing your mindset. I had depression and suicidal thoughts daily from age 9 until I was 24 until I figured out the winning combination to treat my own depression, which I believe is almost entirely health and mindset related.

  6. 4 weeks ago
    Anonymous

    Literally yet to fuck a girl who wasn’t in these.

  7. 4 weeks ago
    Anonymous

    Someone explain to me how microdosing psilocybin is literally the antidote to depression and the molecule is virtually identical to serotonin

    • 4 weeks ago
      Anonymous

      Its not and joe rogan is retarded

      • 4 weeks ago
        Anonymous

        It is moron, I feel great on it

        • 4 weeks ago
          Anonymous

          >takes magic mushrooms
          >wtf I feel excellent
          >snorts meth
          >wow I’ve never had so much energy in my life!
          >takes heroin
          >wow I could drift right off that’s crazy! I could barely close my eyes a minute ago!

  8. 4 weeks ago
    Anonymous

    Lol IST aitists and """depressed""" redditors on suicide watch lmfaooooo did it feel god getting fed the zombie pills?

    • 4 weeks ago
      Anonymous

      >Lol IST aitists and """depressed""" redditors on suicide watch lmfaooooo did it feel god getting fed the zombie pills?
      That's not funny. Their excuse for having a shitty, selfish, secular, self-absorbed attitude was just taken away. Sad.

  9. 4 weeks ago
    Anonymous

    I have no idea why this article spawned a bunch of anti-drug celebration.

    "Chemical imbalance" was literally never a credible theory, and no one serious in academia argued for it. The fact that it is proven, yet again, to not be the cause of depression is not newsworthy.

    We've also known that SSRIs aren't trying to solve a "chemical imbalance". I feel like I'm in an alternate reality when I watch people start waving victory banners against a stance that, as far as the medical community goes, doesn't exist.

    • 4 weeks ago
      Anonymous

      >no one in academia thought this (cope)
      >academia made no serious attempt to correct public opinion on this
      yeah pardon me but I'm still going to shit on "academia" for being a bunch of fucking idiots who let their insights get run off with by media in 80 different directions. Major societal changes are made based off this shit.

      • 4 weeks ago
        Anonymous

        Big pharma pushed media which had millions of civilians walking into doctors offices and demanding pills to fix their and their childrens problems. Survival of the fittest my man

    • 4 weeks ago
      Anonymous

      I'm really just trying to decide if I should continue taking them.

    • 4 weeks ago
      Anonymous

      it's never been accepted medical science either. some people show improvement with SSRIs, and the answer is: we don't know why. we can't even measure serotonin predictably anyway. lastly there is no concept of a chemically balanced brain to begin with, so how the fuck would anyone know what a chemical imbalance even constitutes?

  10. 4 weeks ago
    Anonymous

    They did it the same way they got everyone in the US on oxycodone. By paying government bodies and doctors.

    Everyone is this thread should read Anatomy Of An Epidemic by Robert Whitaker. If you believe even 1/3 of it, it will completely change how you think about psychiatric pharmaceuticals.

  11. 4 weeks ago
    Anonymous

    >Little evidence that serotonin imbalance causes depression
    So what you are saying is....I could just choose to be happy?

  12. 4 weeks ago
    Anonymous

    It's no measure of health to be well adjusted to a sick society

  13. 4 weeks ago
    Anonymous

    This isn't surprising for anybody with a single brain cell. I've said it since I was a teenager, they aren't testing peoples brian chemistry levels when diagnosing and medicating, so the idea that muh imbalance is a joke.

  14. 4 weeks ago
    Anonymous

    Lol this has been known since the 90s

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518691/

  15. 4 weeks ago
    Anonymous

    that means its working

  16. 4 weeks ago
    Anonymous

    A little off topic, but I absolutely despise how normiegays try to sound nerdy and quirky by midwitting the fuck out of endocrine molecules like serotonin and dopamine. Them saying shit like "oh this of a furbaby pupper boosts my serotonin" or "this pic of a cat gave me more dopamine" makes my blood boil. You're not as smart as you think, your "nerdy" hobbies are literally on mainstream television/streaming services. Just stop.

  17. 4 weeks ago
    Anonymous

    Big pharma made billions by pushing a placebo for 50y. You love to see it. At least it wasn't harmful except making it harder to cum

  18. 4 weeks ago
    Anonymous

    Could it be that depression is caused by YOUR LIFE BEING FUCKED UP BEYOND BELIEF WITH NO HOPE FOR A LONG AS FUCK TIME? Shit, must be because of imbalanced humors and fucking sneed oul!

  19. 4 weeks ago
    Anonymous

    So why do people who use too much MDMA develop long term depression/anxiety?
    It negatively affects the serotonin system.

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