no, seriously. it converts to other hormones including allopregnenalone, which is a GABAα allosteric modulator, meaning similar effects to benzos
but apparently, the metabolism of this is unknown for different individuals. people report it raising or lowering test, raising or lowering estradiol, etc
it seems to me that having more hormone precursor allows some peoples body to shift things into correct gear. i feel amazing
Can it elevate prolactin? That's really my only concern with taking pregnenolone. I've already had issues with high prolactin that I keep under control with p5p.
Abstract
Pregnenolone sulfate (PS) is a neuroactive steroid hormone produced in the brain. In this study, the effects of PS on synthesis and secretion of rat pituitary prolactin (PRL) were examined. To accomplish this, GH3 rat pituitary adenoma cells were treated with PS, which showed significantly increased mRNA and protein levels of PRL compared with the control. The mechanism of action responsible for the effects of PS on PRL synthesis and secretion was investigated by pretreating cells with inhibitors of traditional PRL- or the PS-related signaling pathway. PS-stimulated PRL transcription was significantly reduced by inhibitors of PKA, PKC and MAPK, but unchanged by GABAAR and NMDAR inhibitors. Western blotting analysis revealed that the total ERK1/2 level was upregulated in a time-dependent manner following PS treatment. An approximate 10% increase in GH3 cell proliferation was also observed in response to PS relative to the control. In the animal study, levels of PRL in the pituitary and in serum were elevated by PS. PS-stimulated PRL synthesis was also found to be associated with decreased expression of PRL target genes such as GNRH1, FSHB and LHB. These findings show that PS upregulates PRL synthesis and secretion in vivo and in vitro via MAPK signaling, suggesting that it has the potential for use as a therapeutic hormone to treat PRL-related disorders such as hypoprolactinemia and low milk supply.
Yeah awesome right? Now try to cum.
ok I'll go get sucked off by my wife and report back
>ok I'll go get sucked off by my wife and report back
OK reporting back
probably the most i have ever enjoyed ejaculating. like maybe not the single best orgasm if that makes sense, but ejaculating was awesome. it felt like it kept flowing out, like some kind of muscular sensation that normally stands in the way was relaxed instead so i was just freebussin
Aight, i‘m sold.
no, seriously. it converts to other hormones including allopregnenalone, which is a GABAα allosteric modulator, meaning similar effects to benzos
but apparently, the metabolism of this is unknown for different individuals. people report it raising or lowering test, raising or lowering estradiol, etc
it seems to me that having more hormone precursor allows some peoples body to shift things into correct gear. i feel amazing
i wonder if i'll get breasts. probably worth it!
No, i was actually serious. I already put it in the cart. Sounds worth a try.
I was not taking this one I was taking another pill that is 25mg on amazon
a lot of people seem to use 2-5mg sublingual
Nah i will get the 100mg one. Wish me luck.
blast and cruise
also some hyper masculine fitness dude eats this religiously i cant remember who. hes probably on mad roids simultaneously though
chase irons
the dick numbing effect is pretty cool if you're into really sadistic edging and denial play
dick numbing? my dick feels throbbing like some kind of jungle spaniard
Yeah awesome right? Now try to cum.
Explain
Wut
Will this make me last longer?
as in extend your life?
No. Extend the time I'm fricking your mom
then what?
I want to last longer in bed.
Indicated that this would make it harder to cum. I wanted more info.
It doesn't. You're looking for either dapoxetine or P5P
Can it elevate prolactin? That's really my only concern with taking pregnenolone. I've already had issues with high prolactin that I keep under control with p5p.
Abstract
Pregnenolone sulfate (PS) is a neuroactive steroid hormone produced in the brain. In this study, the effects of PS on synthesis and secretion of rat pituitary prolactin (PRL) were examined. To accomplish this, GH3 rat pituitary adenoma cells were treated with PS, which showed significantly increased mRNA and protein levels of PRL compared with the control. The mechanism of action responsible for the effects of PS on PRL synthesis and secretion was investigated by pretreating cells with inhibitors of traditional PRL- or the PS-related signaling pathway. PS-stimulated PRL transcription was significantly reduced by inhibitors of PKA, PKC and MAPK, but unchanged by GABAAR and NMDAR inhibitors. Western blotting analysis revealed that the total ERK1/2 level was upregulated in a time-dependent manner following PS treatment. An approximate 10% increase in GH3 cell proliferation was also observed in response to PS relative to the control. In the animal study, levels of PRL in the pituitary and in serum were elevated by PS. PS-stimulated PRL synthesis was also found to be associated with decreased expression of PRL target genes such as GNRH1, FSHB and LHB. These findings show that PS upregulates PRL synthesis and secretion in vivo and in vitro via MAPK signaling, suggesting that it has the potential for use as a therapeutic hormone to treat PRL-related disorders such as hypoprolactinemia and low milk supply.
ok I'll go get sucked off by my wife and report back
Noice. Will this make me lactate or what?
I already have breasts and im gonna get them cut off so there will be nothing to grow, so im not worried about it
prolactin also makes you lazy and disinterested in life
What if i am female though?
Well, we‘ll see about that.
>What if i am female though?
post em
Signs of high prolactin are pretty easy to notice. Lack of interest in life and low libido are pretty common.
For men?
>
>ok I'll go get sucked off by my wife and report back
OK reporting back
probably the most i have ever enjoyed ejaculating. like maybe not the single best orgasm if that makes sense, but ejaculating was awesome. it felt like it kept flowing out, like some kind of muscular sensation that normally stands in the way was relaxed instead so i was just freebussin
ok report section beta 11-2.a
wife says "it was a lot, more than usual"
Thank you for your (wife's) service anon
I take it 1-2 times a week. Seems to keep me strong and energetic
buy an ad pharma shill
>taking supplements
ngmi
What’s the alternative
not taking supplements
>blatent advertising from supplement manufacturer
MOOOOOOODDDS
3/4th of this thread is (You) supplement merchants
kys