Is hair loss really settled science? What are the known causes/treatments?

Is hair loss really settled science? What are the known causes/treatments?

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  1. 2 months ago
    Anonymous

    Other than fringe cases caused by malnutrition or stress or whatever balding is caused by androgens attaching to androgen receptors in the scalp hair follicles, the most androgenic of them being dht. Reducing dht levels is the most reliable and effective way to prevent balding and potentially reverse it if done early enough. You can reliably reduce dht levels by taking a 5ar inhibitor. None of this is new or controversial.

    • 2 months ago
      Anonymous

      How safe are these 5ar inhibitors? what are the known side effects?

      • 2 months ago
        Anonymous

        major known side effects: manbreasts, reduced libido, limp dick. but it only affects a very tiny subset of people taking medication.

      • 2 months ago
        Anonymous

        Fairly safe.

        >caused by androgens attaching to androgen receptors in the scalp hair follicles
        >androgens attaching to androgen receptors
        aren't they supposed to do that by default? wtf does that have to do with hair follicles?

        Hair follicles have androgen receptors. Attaching to receptors is how hormones exert their effects in different tissues of the body.

        • 2 months ago
          Anonymous

          >purpose of androgen receptors is to receive androgens
          >this is somehow related to hair follicles
          Excuse me?

          • 2 months ago
            Anonymous

            I literally just explained it to you. There are androgen receptors in the papilla of the hair follicles on the scalp. Dht binds to these receptors and exerts its effects. The effects of androgens (and hormones in general) is tissue selective. In the scalp androgens reduce the length of the anagen stage of hair growth which causes balding over time.

            • 2 months ago
              Anonymous

              >In the scalp androgens reduce the length of the anagen stage of hair growth
              proof?

              • 2 months ago
                Anonymous

                It's well understood and widely documented and has been for decades now. There are numerous studies on pubmed demonstrating it but I'm guessing for some reason you want to ignore that because you have some weird agenda or schizo alternative theory.

              • 2 months ago
                Anonymous

                >science is settled
                Thanks professor chud.

              • 2 months ago
                Anonymous

                What's your alterate theory for why higher scalp dht levels directly correlate with greater hair loss in test subjects, why reducing dht with 5ar inhibitors halts hair loss and how researchers were literally able to observe how dht negatively effected hair growth in vitro using human cells via the beta-catenin pathway?

              • 2 months ago
                Anonymous

                >In the scalp androgens reduce the length of the anagen stage of hair growth
                proof?

              • 2 months ago
                Anonymous

                https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989660/
                There's literally hundreds of studies on the relationship between dht and hair loss, anon.

              • 2 months ago
                Anonymous

                >hundreds of studies
                >Mice and In Vitro Organ Culture
                Human studies preferred.

                Have another
                https://pubmed.ncbi.nlm.nih.gov/32731328/

                >Review Hormonal Effects on Hair Follicles
                >Review
                ???

              • 2 months ago
                Anonymous

                In vitro is human cells. You asked for for evidence of this claim:
                how researchers were literally able to observe how dht negatively effected hair growth in vitro using human cells via the beta-catenin pathway?
                Which is why I posted it.

              • 2 months ago
                Anonymous

                A review is an anslysis of data from multiple studies. Holy shit, you're a fricking moron

              • 2 months ago
                Anonymous

                Dude, frick off, you're barely sentient

              • 2 months ago
                Anonymous

                Have another
                https://pubmed.ncbi.nlm.nih.gov/32731328/

    • 2 months ago
      Anonymous

      >caused by androgens attaching to androgen receptors in the scalp hair follicles
      >androgens attaching to androgen receptors
      aren't they supposed to do that by default? wtf does that have to do with hair follicles?

    • 2 months ago
      Anonymous

      >the most androgenic of them being dht
      so masturbation does cause balding

  2. 2 months ago
    Anonymous

    >What are the known causes?
    Bad genes. That's why you never hear women say how they love bald/balding men.

    >What are the known treatments?
    You can try chemically castrating yourself with drugs only to delay the inevitable or go to Turkey, pay lotsa money to delay the inevitable.

  3. 2 months ago
    Anonymous

    >What are the known causes
    Inferior white genetics

  4. 2 months ago
    Anonymous

    Why do you keep making the same hairloss threads on IST over and over again?
    We perfectly know what causes it (DHT, not testosterone) and how to treat it (5ar inhibitors such as finasteride or dutasteride, topical anti-androgens such as RU58841 or pyralutamide and growth stimulants such as minoxidil and stemoxydine). There will be no other treatment since all the ones in the research pipeline are either extremely expensive and only produce mild effects (verteporfin and the HMI-115) or have failed altogether.

    If you are reading this and are balding, you have two options. Either start treatment now or shave it/get a system. There is no magic scalp massage bullshit that works. If you fell for tiktok scams you are moronic and deserve to go bald.

  5. 2 months ago
    Anonymous

    Losing hair is so stupid and annoying I fricking hate it

  6. 2 months ago
    Anonymous

    95%+ of male hair loss is from androgenic alopecia.
    Cause: DHT
    Treatment: Finasteride/Dutasteride

    • 2 months ago
      Anonymous

      proof?

      • 2 months ago
        Anonymous

        u srs?
        https://www.ncbi.nlm.nih.gov/books/NBK278957/

    • 2 months ago
      Anonymous

      >Cause: DHT
      it's not DHT per se, but a genetic sensitivity to androgens

      • 2 months ago
        Anonymous

        >splitting hairs
        It's a sensitivity to DHT

      • 2 months ago
        Anonymous

        You can have low-moderate DHT but high sensitivity to it or high DHT but low-moderate sensitivity to it. In either case you will lose hair. As a general rule of bro-science, the earlier you got a beard and body hair the higher your DHT.

  7. 2 months ago
    Anonymous

    the main cause of hair loss is creatine

    • 2 months ago
      Anonymous

      t. creatinelet

    • 2 months ago
      Anonymous

      i lost more hair on creatine than i did on tren

      • 2 months ago
        Anonymous

        i lost alot of hair on creatine not even joking

        yep

        Creatine doesn't cause hairloss because there is no mechanism by which creatine could increase 5ar activity. The only study showing some effect on hormone levels was flawed due to the treatment group having lower serum DHT levels than the placebo group to begin with.

        • 2 months ago
          Anonymous

          do you know how much money the industry makes on creatine sales?

          whey powder and creatine are trillion dollar markets. any study that throws shade on those products are promptly buried and squashed

          and fyi. anything legal is not worth using. all creatine does is make you hold more water aka makes you look bloated and fat, but i guess nattards need something to cope with in their pathetic lifting existence. muh creatine gainzzzzzz

          • 2 months ago
            Anonymous

            What I know is that conspiracy morons deserve a beating. Creatine doesn't cause hairloss and aliens aren't real.

            • 2 months ago
              Anonymous

              everyone agrees that creatine causes hair loss. not to a similar degree as roids, obviously.
              but it does cause hair loss 100%

              • 2 months ago
                Anonymous

                No it doesn't.

              • 2 months ago
                Anonymous

                post body. i want to see your creatine gut

              • 2 months ago
                Anonymous

                I don't use creatine because it disturbs my sleep.

              • 2 months ago
                Anonymous

                hahah what. what a fricking pussy

    • 2 months ago
      Anonymous

      i lost alot of hair on creatine not even joking

      • 2 months ago
        Anonymous

        yep

    • 2 months ago
      Anonymous

      My friend wouldn't shut the frick up about creatine on how I'm missing out on gains by not taking it.
      Then last year he made a trip to Turkey.

      • 2 months ago
        Anonymous

        theres no such thing as creatine gains. unless people consider 3 kilos of extracellular fluid retention as "gainzzz"

  8. 2 months ago
    Anonymous

    Before any of you gays start slathering your Norwood 0.5 scalps in sneed science oils, google the (long) list of shampoo ingredients that cause hair loss, then switch to bar soap for awhile.

    • 2 months ago
      Anonymous

      only tards use shampoo
      for millions of years humans had immaculate perfect hair, and then we started using shampoo and suddenly 2/3rds of men are going bald before hitting 30

      • 2 months ago
        Anonymous

        This has been disproven by Roman inscriptions of people making fun of baldies. It's an issue that precedes humanity.

        • 2 months ago
          Anonymous

          post roman inscriptions or else you just saw it in a dream

          cuz i know that caveman inscriptions says otherwise

          • 2 months ago
            Anonymous

            >, but even having superfluous hair plucked out, as some have charged; while his baldness was a disfigurement which troubled him greatly, since he found that it was often the subject of the gibes of his detractors. Because of it he used to comb forward his scanty locks from the crown of his head
            https://lexundria.com/suet_jul/45-53/r

    • 2 months ago
      Anonymous

      >NW0.5
      I wish. finasteride has brought me back to a NW2 but without it my entire scalp was thinning and receding, even the back and sides. Shampoo is a meme.

  9. 2 months ago
    Anonymous

    Been on finasteride for 99 days straight, started on the 22nd of September.
    AMA

    • 2 months ago
      Anonymous

      is your willy alright?

      • 2 months ago
        Anonymous

        No trouble getting hard, but I don't get any random erections anymore which was a noticeable difference.

        when did you start?

        22/09/2023 at 11:04 AM. I have an excel sheet.

        • 2 months ago
          Anonymous

          Fin can change your T-E ratio. Try to account for other risk factors for erectile function such as high cholesterol or low NO levels.

          • 2 months ago
            Anonymous

            I'm not going to unequivocally attribute it to finasteride, but it's the only change I noticed after getting on it. Could just be a psychological thing though.

    • 2 months ago
      Anonymous

      when did you start?

    • 2 months ago
      Anonymous

      Noob, I've been on fin for nearly 18 months with zero issues whatsoever. Still regularly shedding though and my hairline is regrowing only very, very slowly, one hair at a time.

      • 2 months ago
        Anonymous

        18 months, very nice. Have you thought of starting minox?

        • 2 months ago
          Anonymous

          I know I can't be assed to use minox on my hairline every day hence I'm still waiting for the 36-40 month mark at which results should've peaked. Once I have the money I will probably use either RU or pyr for half a year and hope finasteride can maintain gains made this way.

          • 2 months ago
            Anonymous

            That's what has put me off minox, that and if you stop all the hair you grew with it just drops out of your head.

            • 2 months ago
              Anonymous

              I've considered oral minoxidil aswell but I'm too scared of fluid buildup around my heart. Supposedly low dose oral minoxidil doesn't have that side effect (which only occurs at 10-80mg daily in 5% of people) but since my hair is not that bad, it's not worth it for me.

              • 2 months ago
                Anonymous

                MUH FLUID BUILDUP BRAH?

                jesus christ grow a pair homosexual

              • 2 months ago
                Anonymous

                I've been taking oral minox for a few months. Here's my review.

                >had some chest pains but I was taking 10mg per day, reduced dose by a lot to only 5mg per day and that went away entirely
                >hair definitely thicker, eyebrows and eyelashes too, and nose hair which now I gotta pluck like an old man
                >didn't restore any ground to the hairline unfortunately like some of the werewolf bro transformations I've seen but did bolster the strength behind the line
                >I swear to frick it has aged my face, I look 5 years older that I did taking it

                On the skin aging, minoxidil has been shown to inhibit collagen production. I'm not just on placebo on it. The beardbros who use it on their face have reported this as well when trying to beef up their facial hair. Having it coursing in your system daily stands to reason it will inhibit collagen production.

                However, topical minoxidil did nothing for me. It's this or nothing.

              • 2 months ago
                Anonymous

                Oral minoxidl supposedly increases elastin production aswell.

              • 2 months ago
                Anonymous

                I've seen that it supposedly increases elastic in blood vessels. There's always the possibility that my perceived face aging is from sleeping like shit due to a new job and sun exposure over the summer, but it was a pretty noticeable difference over the last year. I went form people guessing my age at 22 to 32. I'm 30.

              • 2 months ago
                Anonymous

                >fluid buildup
                Yeah bro that fluid is called blood lmao it's supposed to go to your heart, pussy ass b***h god damn.

  10. 2 months ago
    Anonymous

    Testosterone metabolizes via the 5ar2 enzyme into Dihydro-Testosterone which men's scalp follicles have a spectrum of negative sensitivity to based on genetics.

    It's as simple as that. DHT damage to the follicle is the root cause. To stop hairloss you need to stop DHT damaging your follicles. There are a number of approaches to this.

    1. Ingest a 5ar2 inhibitor to saturate your body in it and lower your system DHt thus lowering scalp DHT.
    2. Apply a 5ar2 inhibitor to your scalp directly to lower DHT locally, while accepting that some will also go into your system.
    3. Use varios other topical anti-androgens like Pyrilutimide and RU88541 which are currently experimental.
    4. Use """""""""""""""natural methods"""""""""""" like Saw Palmetto, Peppermint Oil, Castor Oil, and others which haven't been shown effective.

    >But what about minoxidil?
    Minoxidil is a growth stimulant but does not prevent the destruction of your follicles.

    >But what about a transplant?
    The non-transplant hairs will continue to die off leaving you with a moron looking hairline of transplant material only up there. If you get a transplant you have to take one of the above treatments to maintain the rest.

    tl;dr - You have to take the pill.

    • 2 months ago
      Anonymous

      That sums it up pretty well. Note on pyrilutamide, you should use at least the 1-1.5% solution because the 0.5% solution failed to improve hair beyond placebo. Kintor shot themselves in the knee by using such a low dose in the phase 3 trials.

  11. 2 months ago
    Anonymous

    WE CAN TRAVEL HYPERSPACE AND TRAVERSE THE QUANTUM VERSE

    but we cannot regrow hair

    life is a cruel joke.

  12. 2 months ago
    Anonymous

    Shave your head you insecure homosexual.

    • 2 months ago
      Anonymous

      lmao NO

      never go bald. hair is life

      id rather wear a wig than be bald ong

      • 2 months ago
        Anonymous

        You sound like a troon.

        • 2 months ago
          Anonymous

          Baldies are losers

        • 2 months ago
          Anonymous

          coolstory baldie

    • 2 months ago
      Anonymous

      Why do you feel the need to be an evangelist? Shave your head if you want, we'll do something else.

      • 2 months ago
        Anonymous

        You can’t always rely on chemicals to sort your life’s problems.

        • 2 months ago
          Anonymous

          Not always but in many cases you absolutely can. We live in the 21st century, not in 40,000BC.

        • 2 months ago
          Anonymous

          Right, but in this case you literally can. The only people going bald are stupid at this point.

          • 2 months ago
            Anonymous

            Imagine being a man and caring so much about your appearance.
            You’re either a sexless queer in your 20’s or a hopeless moron in your 40’s trying to cling onto your youth.

            • 2 months ago
              Anonymous

              Imagine being a 40/50yo schizo boomer on IST IST shitting on people for not wanting to look ugly.
              Get your bald ass outta here.

            • 2 months ago
              Anonymous

              I'm a hopeful moron in my 30's who just in the last couple years seems to have come into an age where hot college girls with issues want me to frick them with my belt around their necks while they call me daddy and I know that will go away if I lose my hair to a certain point. I already have the "mature hairline" that I have to style a certain way to look good and it's teetering on the brink of doom. I take my finasteride and some minox and preserve for as long as I can.

              • 2 months ago
                Anonymous

                FairPlay to you mate.
                What shape is your head?

              • 2 months ago
                Anonymous

                I'm 6'6" with a head the size of a large cinder block (I'm not joking, from the bottom of my chin to the top of my dome is a foot of skull). I am on strongman perma-bulk year round to not be a full on alien from Signs looking lanklet. I would not look good bald. I would not be able to "just grow a beard bro" and pull it off. Me being tall and handsome rather than tall and ogre mode hangs largely on maintaining my looksmaxxing.

                It is what it is. At best if I ever decide to give up I plan to just start roiding and turn myself into Sagat from Street Fighter with the full shaved head.

              • 2 months ago
                Anonymous

                I respect people like you who are sentient enough to know what works for them via analysis

                instead of those morons who be like if i get a haircut then maybe ill be good looking herp derp

              • 2 months ago
                Anonymous

                you can really tell when something is written by a tall person, it comes off as way more intelligent than the tarded musings of manlets

                t. fellow 6'6

              • 2 months ago
                Anonymous

                The difference between a manlet and a man is that the manlet will try to pull you down to their level while the man will try to pull you up to his level.

              • 2 months ago
                Anonymous

                Based difference identified identifying differences.

              • 2 months ago
                Anonymous

                >tallgay not understanding that he could literally be a hideous monster and girls would still like him because he's tall
                Fricking hate you stringbean Black folk like you wouldn't believe.

              • 2 months ago
                Anonymous

                6'6 guy here. I can assure you this is not the case

                (perhaps except for in USA because they are height obsessed)

              • 2 months ago
                Anonymous

                nta but being bald is like a 8" malus for attractiveness.

    • 2 months ago
      Anonymous

      JASON STATHAM THE ROCK VIN DIESEL

      lmao NO

      never go bald. hair is life

      id rather wear a wig than be bald ong

      Yeah this.

      I've seen that it supposedly increases elastic in blood vessels. There's always the possibility that my perceived face aging is from sleeping like shit due to a new job and sun exposure over the summer, but it was a pretty noticeable difference over the last year. I went form people guessing my age at 22 to 32. I'm 30.

      Maybe try tretinoin and sunscreen?

    • 2 months ago
      Anonymous
  13. 2 months ago
    Anonymous

    high test = balding
    no other way around it.

    • 2 months ago
      Anonymous

      Testosterone is neutral for beneficial for hair growth. It's DHT that's killing your hair follicles.
      Bald men aren't manly, they are old.

      • 2 months ago
        Anonymous

        Any cure for wrinkles?
        You looksmaxing gays are insufferable.

        • 2 months ago
          Anonymous

          Of course I do have suggestions.
          Supplements
          -hyluronic acid
          -collagen peptides
          -astaxanthin
          -MSM
          -vitamin C

          Cremes/gels/sprays
          -sunscreen
          -tretinoin
          -moisturizer
          -cleanser
          -exfoliator

    • 2 months ago
      Anonymous

      im on 3 grams of test and not close to balding

      balding is genetic, not a symptom of excess DHT

      balding is more like a genetic defect than anything really

      • 2 months ago
        Anonymous

        >balding is genetic, not a symptom of excess DHT
        DHT is directly resposble for balding. If you lower DHT, you stop balding in over 90% of cases and regrow hair in over 2/3 of cases. There is a clear mechanism for how DHT does this too.

        • 2 months ago
          Anonymous

          mate ive been on oral methylated DHTs, tren and grams of test for years

          theres no 1:1 relationship and causation between DHT and balding

          balding is 99% genetic, its a genetic defect, not a symptom of hormonal influence

          • 2 months ago
            Anonymous

            >theres no 1:1 relationship and causation between DHT and balding
            There literally is.
            We know from clinical RCTs that lowering DHT via 5aris stops and reverses balding. From in-vitro studies, we even know how DHT destroys human hair follicles.
            >balding is 99% genetic
            And how do you think GENETICS cause balding? Either you have too many androgen receptors at your hair follicles or you have too much DHT. In either case lowering DHT helps.

            • 2 months ago
              Anonymous

              yea all that is true

              however theres a cap on how far your balding can go and that is determined by genetics

              take a guy who isnt genetically prone to balding and soak his hair in literal methylated dht. He still wont go bald

              Now take a guy who is prone to balding and you will have to neuter him completely just to halt the shedding a bit

              Therefore we can conclude that genetics > hormones plays a much bigger role in regards to balding

              • 2 months ago
                Anonymous

                >however theres a cap on how far your balding can go and that is determined by genetics
                Given enough exposure to DHT, every single hair follicle on your scalp can and will eventually die if you are even a little bit susceptible to it.
                >take a guy who isnt genetically prone to balding and soak his hair in literal methylated dht. He still wont go bald
                It depends. DHT derived steroids can cause balding in people who would otherwise not be balding naturally.
                >Now take a guy who is prone to balding and you will have to neuter him completely just to halt the shedding a bit
                Actually no. We have multiple 10 year studies in Italy, Japan and South Korea showing that both finasteride and dutasteride will maintain and regrow hair in over 90% of cases. Once DHT is low enough, you will not bald any more.
                >Therefore we can conclude that genetics > hormones plays a much bigger role in regards to balding
                As I explained, part of GENETICS is high DHT/5ar activity which can be safely and effectively suppressed via 5aris.

              • 2 months ago
                Anonymous

                do you know what methylated DHT orals are? i assure you if everyone had the same proclivity for going bald, then I would be bald by now. Yet I am not

              • 2 months ago
                Anonymous

                Genetic anomalies will always exist. Reagan had a perfect hairline at the age of 80 while some poor 16yo somewhere is already a NW5.

              • 2 months ago
                Anonymous

                Side effects of DHT?

          • 2 months ago
            Anonymous

            How old are you? I used to be like this until I hit my late 30's. There seems to be some age component to dht influenced hair loss. I shed slowly on my trt dose now, when before I could blast grams and use mast with no effects

  14. 2 months ago
    Anonymous

    >settled science
    tf u mean
    How can it be settled when we don't know how to cure or prevent it, let alone without side effects

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