Minox surpresses testosterone

Minox bros....

>Minoxidil treatment resulted in a 0.22 fold change for 5α-R2 (p < 0.0001). This antiandrogenic effect of minoxidil, shown by significant downregulation of 5α-R2 androgen gene expression in HaCaT cells, may be one of its mechanisms of action in alopecia.
https://pubmed.ncbi.nlm.nih.gov/30064598/

>Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling. These tests revealed that minoxidil suppressed AR-related functions, decreasing AR transcriptional activity in reporter assays, reducing expression of AR targets at the protein level, and suppressing AR-positive LNCaP cell growth.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039155/

oh nonononono....

>https://duckduckgo.com/?q=!g+"minox+sides"+site%3Areddit.com&hps=1&ia=web
OH NONONONONON HAHAHAHAHAHA!

  1. 2 months ago
    Anonymous

    JUST

  2. 2 months ago
    Anonymous

    tldr: the reason minox reverses hair loss, biologically, is because it suppresses testosterone production. this wasn't previously thought to be possible but new research since 2017 shows that minoxidil indeed lowers testosterone.

    people talk about fin being a "chud drug" because it suppresses androgens to reverse hairloss, but minoxidil does the exact same thing! fin and minox work by LITERALLY turning you into a woman.

    • 2 months ago
      Anonymous

      Minox bros....

      >Minoxidil treatment resulted in a 0.22 fold change for 5α-R2 (p < 0.0001). This antiandrogenic effect of minoxidil, shown by significant downregulation of 5α-R2 androgen gene expression in HaCaT cells, may be one of its mechanisms of action in alopecia.
      https://pubmed.ncbi.nlm.nih.gov/30064598/

      >Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling. These tests revealed that minoxidil suppressed AR-related functions, decreasing AR transcriptional activity in reporter assays, reducing expression of AR targets at the protein level, and suppressing AR-positive LNCaP cell growth.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039155/

      oh nonononono....

      >https://duckduckgo.com/?q=!g+"minox+sides"+site%3Areddit.com&hps=1&ia=web
      OH NONONONONON HAHAHAHAHAHA!

      Does it surpress DHT or all testosterone? Is it local to the scalp or systematic?

      • 2 months ago
        Anonymous

        it's systemic for all androden receptors (thus it would theoretically affect both DHT and T) even when applied topically, although the 2nd study also found greater localized suppression.

      • 2 months ago
        Anonymous

        Fin prevents test from being converted to DHT. It literally INCREASES serum testosterone levels. The reason it's memed as a "chud drug" is because it's included in the regimen to prevent male pattern baldness which is obviously detrimental if you're trying to pass as a woman

        • 2 months ago
          Anonymous

          False. Fin as the same antiandrogen antialopecia MoE as minoxidil biochemically, which, if acting upon androgen receptors in toto, affects T and DHT efficacy simultaneously regardless of changes to DHT:T ratio conversion levels.

          • 2 months ago
            Anonymous

            lying on the internet

            > attempt to use Minoxidil
            > doesn't work for me personally
            > make up bullshit to get dudes it actually works for to stop
            Fuck off with your copium

            • 2 months ago
              Anonymous

              >biochemical studies hurt my feefees, therefore you're lying!
              I guess the minox really did make you into a woman, kek

          • 2 months ago
            Anonymous

            >biochemical studies hurt my feefees, therefore you're lying!
            I guess the minox really did make you into a woman, kek

            https://www.goldjournal.net/article/S0090-4295(03)00661-7/fulltext
            >Finasteride treatment led to a modest, but significant (P <0.001), increase relative to placebo in serum testosterone, with this increase greatest in patients who had low baseline testosterone levels.
            Your retarded speculation based on biochemical studies you don't fucking understand doesn't disprove real empirical data.

            • 2 months ago
              Anonymous

              see

              People who suppress DHT to maintain a girly hairline are playing with biochemical consequences they don't understand

              DHT is related to lower systemic inflammation and faster healing of inflammatory response
              >Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice
              https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504698/

              DHT is associated with lower all-cause mortality, increased lipid synthesis, delayed cognitive decline with age, and significantly lower diabetes risk/insulin resistance
              >Intracellular DHT is a more potent androgenic agonist than T and increases total serum T.
              https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459338/

              DHT suppresses whole body inflammatory diseases (which range from things like acne to cancer)
              >Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation
              https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552015/

              DHT robustly increases bone density and skeletal strength
              >Dihydrotestosterone, a robust promoter of osteoblastic proliferation and differentiation
              https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651475/

              Suppression of DHT is associated with long-term male specific cancers
              >The Loss of Masculinity With Declined Serum DHT Is Associated With High Risk of Carcinoma in Chinese Men
              https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339940/

              DHT is associated with male neurogenesis and ability to learn new things
              >Androgens Enhance Adult Hippocampal Neurogenesis in Males but Not Females
              https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736050/

              DHT is linked to increased muscular hypertrophy
              >Androgens interacts with exercise through the mTOR pathway to induce skeletal muscle hypertrophy
              https://pubmed.ncbi.nlm.nih.gov/29472733/

              DHT is linked to longer stamina while simultaneously burning more fat during cardio
              >Role of dihydrotestosterone in whole-body energy utilization during acute running exercise
              https://pubmed.ncbi.nlm.nih.gov/30149420/

        • 2 months ago
          Anonymous

          Oh my fucking God. Why do fittards think that 8 years of elementary education and 3 years of lifting equals a medical diploma? If it blocks DHT conversion then more T will be left. It means the aromatase enzyme, which produces estradiol, will have a higher chance of picking up T and turning it into E2, thus more female hormone. Please stop spreading misinfo.

          • 2 months ago
            Anonymous

            It does a hair growth thing too possibly by increased blood flow, the effect was discovered because it was originally trialed as blood pressure medication in women and they got hairy.

            Also if you read the abstract it seems to locally limit the production of the enzyme that makes DHT, not blocking the enzyme like fin

            holy cope. read the articles gay, it downregulates androgen RECEPTORS, not just DHT. it literally decreases the amount of usable T, it doesn't just affect DHT:T conversion ratio. new pharmacology studies are showing that suppressing DHT leads to total androgen down-regulation systemically.

            you're taking a fucking chud drug, if you actually read the articles you'll see total serum T (not just DHT) DECREASES with minox use, even topically and locally!

            How much fin should I start with? More mass more ass said that you should start with 0,25mg to begin with, is he right?

            none if you value your health. I'm sure you'll ignore all the data on testosterone-based dysfunction though.

            • 2 months ago
              Anonymous

              1. I posted this

              Oh my fucking God. Why do fittards think that 8 years of elementary education and 3 years of lifting equals a medical diploma? If it blocks DHT conversion then more T will be left. It means the aromatase enzyme, which produces estradiol, will have a higher chance of picking up T and turning it into E2, thus more female hormone. Please stop spreading misinfo.

              and not this

              It does a hair growth thing too possibly by increased blood flow, the effect was discovered because it was originally trialed as blood pressure medication in women and they got hairy.

              Also if you read the abstract it seems to locally limit the production of the enzyme that makes DHT, not blocking the enzyme like fin

              , you fucking mongoloid.
              2. The post I replied to was about finasteride and not minoxidil or the article in OP, how about you read what you're replying to before posting, gay?
              3. Bold of you to assume what drugs a stranger on the internet is taking.
              4. have a nice day.

        • 2 months ago
          Anonymous

          lol time for your chud pills you fucking idiot no wonder your brain doesnt work

          >tldr kys

    • 2 months ago
      Anonymous

      >Turns you in to a woman
      >Increases hair growth
      what

      • 2 months ago
        Anonymous

        KWAB.
        see

        >these studies are bad becaue they disagree with my feelings
        you're a brainlet.

        Minox doesn't increase hair growth through T upregulation. Minox increases bloodflood dermally while simultaneously decreasing nondermal systemic BP. We know the MoE. Androgen side effects, unlike fin, were not until recently even scientifically investigated. Because of the MoE of min, it can simultaneously lower testosterone while increase hair growth because both are effected through differing MoE. New research is showing that, yes, independently of topical hair follicle stimulation, min (like fin) has a separate effect on blood T levels (not just DHT levels).

    • 2 months ago
      Anonymous

      >turning you into a woman
      Making you less of a man. I still wouldn't take that shit, but the distinction is important. You can have too high or too low levels of both sex hormones at the same time.

    • 2 months ago
      Anonymous

      balding is still worse

  3. 2 months ago
    Anonymous
  4. 2 months ago
    Anonymous

    On the flip side...

    >The effects of creatine and creatine plus beta-alanine on strength, power, body composition, and endocrine changes were examined during a 10-wk resistance training program in collegiate football players. Thirty-three male subjects were randomly assigned to either a placebo (P), creatine (C), or creatine plus beta-alanine (CA) group. [...] Resting testosterone concentrations were elevated in C.
    https://pubmed.ncbi.nlm.nih.gov/17136944/

    >Levels of DHT and T increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01).
    >https://pubmed.ncbi.nlm.nih.gov/19741313/

    Creatine INCREASES testosterone. It is also well known that creatine also can accelerate hairloss. Hairloss, by connection with our minox/fin and creatine findings, is linked to higher testosterone biologically. Thus, we can assume bald men were sexually selected for over time for reproductive capability. In short, only little boys and low test "men" have their hair into their late 20s/30s, quite literally speaking. If you don't have a receding hairline, you're not a man.

    • 2 months ago
      Anonymous

      Most of the posters on this board don't care about being men, they just want women.

    • 2 months ago
      Anonymous

      Additionally, higher male testosterone levels are linked to
      1. better mental heath
      2. more strength and athletic ability
      3. higher sexual fertility
      4. increased energy
      5. better cognitive ability
      6. more easily gained muscle mass
      7. faster reflexes and decision making ability
      8. more assertiveness and aggression
      9. higher facial feature attractiveness
      10. less risk of chronic disease over time

      Thus, to the all the pussies on this board:

      USE CREATINE, NOT FIN/MINOX (UNLESS YOU ARE A LITERAL chud). DO YOU WANT TO LIFT HARD? DO YOU WANT TO MOG? OR DO YOU WANT TO BE A WOMAN?

      /thread.

      • 2 months ago
        Anonymous

        Checked and based.

      • 2 months ago
        Anonymous

        >Additionally, higher male testosterone levels are linked to
        >1. better mental heath
        Kek yeah lets see how good your mental health is when you look like mr fucking burns fuck baldness. But i do kind of agree i think just get a wig if you can't pull of the shaved look.

    • 2 months ago
      Anonymous

      You have a very low IQ and zero critical thinking skills. I would unironically kill myself, if I were you.
      Minox has been on the market for decades, and it has been investigated heavily, since cracking it's mechanism of action could lead to the development of new, more effective and patentable drugs. If it worked through simply suppressing T systemically, everyone would know by now.
      Additionally, minox is known to cause beard growth when applied to the face topically, and hair growth all over the body is a known side effect when taken orally. Simply suppressing T wouldn't cause beard and body-hair growth like that.
      At most, topical minox may suppress androgens in the skin but it's most likely a lot less potent than other topical anti-androgens, like RU or Fluridil.

      >Creatine INCREASES testosterone
      WRONG
      >Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (can't link it, IST thinks it's spam)
      >To date, 12 other studies have investigated the effects of creatine supplementation (i.e. doses ranging from 3-25 g/day for 6 days to 12 weeks) on testosterone. Two studies reported small, physiologically insignificant increases in total testosterone after six and seven days of supplementation [65, 66], while the remaining ten studies reported no change in testosterone concentrations. In five of these studies [67,68,69,70,71], free testosterone, which the body uses to produce DHT, was also measured and no increases were found.

      • 2 months ago
        Anonymous

        >NO, creatine can't make me more masculine and minox/fin make me more feminine!
        >Why? IT JUST CAN'T OK? NOOOOOO NONONONONONO THIS CAN'T BE HAPPENING TO ME IST TOLD ME THAT CREATINE IS LE BAD AHHHH

        • 2 months ago
          Anonymous

          >no argument

          • 2 months ago
            Anonymous

            >these studies are bad becaue they disagree with my feelings
            you're a brainlet.

            Minox doesn't increase hair growth through T upregulation. Minox increases bloodflood dermally while simultaneously decreasing nondermal systemic BP. We know the MoE. Androgen side effects, unlike fin, were not until recently even scientifically investigated. Because of the MoE of min, it can simultaneously lower testosterone while increase hair growth because both are effected through differing MoE. New research is showing that, yes, independently of topical hair follicle stimulation, min (like fin) has a separate effect on blood T levels (not just DHT levels).

            • 2 months ago
              Anonymous

              >New research is showing that, yes, independently of topical hair follicle stimulation, min (like fin) has a separate effect on blood T levels (not just DHT levels).
              It doesn't show that, that's just your speculation.

              >these studies are bad becaue they disagree with my feelings
              You mean like when you disregarded the fact that most studies show that creatine has no effect on T or DHT?

              frens, I've taking minox orally (drinking it) for the past 4 months, should I stop ?

              Oral minoxidil has dangerous cardiovascular side-effects. You should stop.

      • 2 months ago
        Anonymous

        good post

      • 2 months ago
        Anonymous

        based

    • 2 months ago
      Anonymous

      That study is dogshit. Tiny sample size and hasn't been replicated. The dozen or so studies that did try to replicate it found no discernible difference between DHT levels from Creatine.

    • 2 months ago
      Anonymous

      >quite literally speaking. If you don't have a receding hairline, you're not a man.
      Is this news to people?
      Part of being a man and having DHT is having your hairline receed. Much like being a women and having estrogen makes your tits grow.
      I have no idea why in the last 50 years men have been propagandized into being insecure about being a man and how the garden gnome has all these solutions to sell to you to fix being a man.

      • 2 months ago
        Anonymous

        having high testosterone doesn't necessarily cause hair loss, it still depends mostly on your genetic predisposition. If you are prone to balding having high DHT will simply enhance the effects. That said I agree that it's dumb that men are made insecure for something that's both extremely common and out of their control, but we live in a vain, vain society.

    • 2 months ago
      Anonymous

      >It is also well known that creatine also can accelerate hairloss.
      no it isn't

    • 2 months ago
      Anonymous

      This is the real reason why creatine is the cheat code

    • 2 months ago
      Anonymous

      >If you don't have a receding hairline, you're not a man.
      OH NO NO NO NO BALDCELS SEETHING AND COPING

  5. 2 months ago
    Anonymous

    >significant downregulation
    >significant

    JUST

  6. 2 months ago
    Anonymous

    > attempt to use Minoxidil
    > doesn't work for me personally
    > make up bullshit to get dudes it actually works for to stop
    Fuck off with your copium

    • 2 months ago
      Anonymous

      >PubMed links are bullshit
      >j-just become a chud like me dude! c'mon man PLEASEPLEASEPLEASE
      COPE

    • 2 months ago
      Anonymous

      at this point i legit use it for hair styling only

  7. 2 months ago
    Anonymous
  8. 2 months ago
    Anonymous

    It's best to just stay pure and not suck big pharma dick.

    • 2 months ago
      Anonymous

      or get a wig

  9. 2 months ago
    Anonymous

    Bros... then how the fuck do I get a beard?

    • 2 months ago
      Anonymous

      It does a hair growth thing too possibly by increased blood flow, the effect was discovered because it was originally trialed as blood pressure medication in women and they got hairy.

      Also if you read the abstract it seems to locally limit the production of the enzyme that makes DHT, not blocking the enzyme like fin

  10. 2 months ago
    Anonymous

    >Made in Israel
    Your fault for buying it.

  11. 2 months ago
    Anonymous

    How much fin should I start with? More mass more ass said that you should start with 0,25mg to begin with, is he right?

    • 2 months ago
      Anonymous

      i just hopped onto 1mg a day five months ago, no sides or anything. honestly convinced that 80% of fin sid effects are placebos from how much anxiety people spread about it

  12. 2 months ago
    Anonymous

    It literally doesn't say anything about suppression of testosterone anywhere.

  13. 2 months ago
    Anonymous

    so i should just hop on HRT while saving my hair with fin and min, got it.

  14. 2 months ago
    Anonymous

    Fin + Minox users are chud tier who could've seen this coming with taking hormone medications just for cosmetics...
    At least with this new information they can finally accept their transition.

    • 2 months ago
      Anonymous

      post hairline

      • 2 months ago
        Anonymous

        >post hairline
        Why? I'm not the one who took the path of trying to cope away a normally receding hairline by taking potentially debilitating hormone blockers. Only fin & Minox users have a collection of their hairline to post and obsess over. Enjoy the possible fucked up libido and puffy aged face that can creep up. Your hair will still eventually start receding again despite all the medication you waste money on. It just isn't worth the risk for a solely cosmetic gain that isn't even permanent.

    • 2 months ago
      Anonymous

      REMINDER chudES ARE ON SUICIDE AND THEY WANT YOU TO BE AS WELL!

      Do no take fin baldfags, embrace being a man instead of taking chud drugs!

      post hairline

      here

  15. 2 months ago
    Anonymous

    Do you guys think there is any point in stacking fin/creatine or will they just cancel each other out?

    • 2 months ago
      Anonymous

      Google the article titled "Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?", I can't link it thanks to the shitty spam filter. Creatine most likely doesn't affect DHT levels but if you're still scared that it will cancel out fin then just get a DHT test to calm yourself down.

  16. 2 months ago
    Anonymous

    Fin is saving my hair.

    Hairloss has slowed down significantly over the last 6 weeks, new baby hairs have sprouted. I was told that positive results and serious regrowth start to be seen between 3 and 6 weeks after starting

    • 2 months ago
      Anonymous

      Same dude, some people get crazy sides, some don't. If it feels right, keep going.

    • 2 months ago
      Anonymous

      >one is greasy other is freshly washed but under the sungarden gnome that mogs the hell out of recessed hairlines
      you still have it good. mine is getting worse every year, now I entered nw3 territory.

    • 2 months ago
      Anonymous

      is that before and after? you went from having hair to still having hair?

    • 2 months ago
      Anonymous

      lol you are literally destroying your body for no change.

      How are you measuring what you didnt lose lol fucking retard

    • 2 months ago
      Anonymous

      Looks like it's still creeping back. Guess you should start taking Tblockers to work on that.

  17. 2 months ago
    Anonymous

    My balls felt funny the day after I used minox in spray form on my beard. I knew something was wrong, so I stopped using it for a few days. Used it again like a week later - same thing happened: weird aching in my balls. So I never used it again. Maybe spray form is much stronger + some of it went into my eye, so I felt the effect immediately.

  18. 2 months ago
    Anonymous

    Rosemary oil's effect is literally equivalent to minoxidil 2%, but I guess without the side effects on test

    • 2 months ago
      Anonymous

      >muh heckin natural remedy
      It's equivalent to 2% minoxidil, which is the weaker version that nobody uses.

  19. 2 months ago
    Anonymous

    >be me
    >27
    >bald af

    I've been thinking about minox / fin but there's so fucking many sides effects that i'd rather keep my dick thick and functional, embrace the bald mode chadbros

    • 2 months ago
      Anonymous

      Minoxidil made my beard full and hair way thicker (hairline was fine before).

  20. 2 months ago
    Anonymous

    Don't fall for the fud. These baldlets want everyone to be bald.

    • 2 months ago
      Anonymous

      Sad how human nature is fundamentally like this to the point where baldlets scream into an anonymous imageboard to cope

      • 2 months ago
        Anonymous

        sponsored by big pharma

        god damn you are a massive gay lol go buy more pills and dont forget your booster shot you dumb moron.

    • 2 months ago
      Anonymous

      That's not it at all, it's clearly fincucks coping hard about their chemical castration and transitioning, should be more than obvious from posts like

      tldr: the reason minox reverses hair loss, biologically, is because it suppresses testosterone production. this wasn't previously thought to be possible but new research since 2017 shows that minoxidil indeed lowers testosterone.

      people talk about fin being a "chud drug" because it suppresses androgens to reverse hairloss, but minoxidil does the exact same thing! fin and minox work by LITERALLY turning you into a woman.

      It could be credible only for the fact that you put minoxidil on topically, almost none of it enters the bloodstream. Its effects on testosterone are not strong enough to be already known when taken orally, it sure as hell isn't going to make a difference applied topically.

      People who suppress DHT to maintain a girly hairline are playing with biochemical consequences they don't understand

      DHT is related to lower systemic inflammation and faster healing of inflammatory response
      >Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504698/

      DHT is associated with lower all-cause mortality, increased lipid synthesis, delayed cognitive decline with age, and significantly lower diabetes risk/insulin resistance
      >Intracellular DHT is a more potent androgenic agonist than T and increases total serum T.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459338/

      DHT suppresses whole body inflammatory diseases (which range from things like acne to cancer)
      >Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552015/

      DHT robustly increases bone density and skeletal strength
      >Dihydrotestosterone, a robust promoter of osteoblastic proliferation and differentiation
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651475/

      Suppression of DHT is associated with long-term male specific cancers
      >The Loss of Masculinity With Declined Serum DHT Is Associated With High Risk of Carcinoma in Chinese Men
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339940/

      DHT is associated with male neurogenesis and ability to learn new things
      >Androgens Enhance Adult Hippocampal Neurogenesis in Males but Not Females
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736050/

      DHT is linked to increased muscular hypertrophy
      >Androgens interacts with exercise through the mTOR pathway to induce skeletal muscle hypertrophy
      https://pubmed.ncbi.nlm.nih.gov/29472733/

      DHT is linked to longer stamina while simultaneously burning more fat during cardio
      >Role of dihydrotestosterone in whole-body energy utilization during acute running exercise
      https://pubmed.ncbi.nlm.nih.gov/30149420/

      Based and dhtpilled.

      • 2 months ago
        Anonymous

        >that you put minoxidil on topically, almost none of it enters the bloodstream
        Actually in both studies where min downregulated androgen receptors it was applied topically. When it was approved in the 90s for topical administration it was thought that there was no transdermal -> bloodstream absorption but recent research after reported min sexual dysfunction (like these studies in the past 5 years) show that min does in fact have systemic androgen suppression even when applied topically.

        • 2 months ago
          Anonymous

          Depends on the amount of suppression also. 0.1% suppression won't change anything.

  21. 2 months ago
    Anonymous

    People who suppress DHT to maintain a girly hairline are playing with biochemical consequences they don't understand

    DHT is related to lower systemic inflammation and faster healing of inflammatory response
    >Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504698/

    DHT is associated with lower all-cause mortality, increased lipid synthesis, delayed cognitive decline with age, and significantly lower diabetes risk/insulin resistance
    >Intracellular DHT is a more potent androgenic agonist than T and increases total serum T.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459338/

    DHT suppresses whole body inflammatory diseases (which range from things like acne to cancer)
    >Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552015/

    DHT robustly increases bone density and skeletal strength
    >Dihydrotestosterone, a robust promoter of osteoblastic proliferation and differentiation
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651475/

    Suppression of DHT is associated with long-term male specific cancers
    >The Loss of Masculinity With Declined Serum DHT Is Associated With High Risk of Carcinoma in Chinese Men
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339940/

    DHT is associated with male neurogenesis and ability to learn new things
    >Androgens Enhance Adult Hippocampal Neurogenesis in Males but Not Females
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736050/

    DHT is linked to increased muscular hypertrophy
    >Androgens interacts with exercise through the mTOR pathway to induce skeletal muscle hypertrophy
    https://pubmed.ncbi.nlm.nih.gov/29472733/

    DHT is linked to longer stamina while simultaneously burning more fat during cardio
    >Role of dihydrotestosterone in whole-body energy utilization during acute running exercise
    https://pubmed.ncbi.nlm.nih.gov/30149420/

    • 2 months ago
      Anonymous

      Based and baldpilled.
      These sissies who grow their hair are the equivalent of hipsters growing a beard and buying oils, combs and scented wax to "groom" their beard (probably not the only thing they groom).
      Stop trying to pretty up, become strong and confident instead.
      That or buy a set of buttplugs to train your asshole so it doesn't tear when I ram your sissy ass.

  22. 2 months ago
    Anonymous

    Tfw used minix for 7 months for a beard when I was 21. Fuck man, are you telling me I could have grown a little more?

    • 2 months ago
      Anonymous

      Also is the damage permanent? Are my hormones permanently fucked or should they be normal now that it's been 6 years later? Worried about my fertility bros

    • 2 months ago
      Anonymous

      Also is the damage permanent? Are my hormones permanently fucked or should they be normal now that it's been 6 years later? Worried about my fertility bros

      >could've grown more
      >at 21
      unlikely, unless you've grown between 20 and 21. I wouldn't worry about any lasting side effects either, bit if you want to be sure just take a fertility test and go to an andrologist. Keep in mind that retards on this board always blow things out of proportion, if a study said that eating 2kg of turnips a day could increase your risk of cancer by 0.1% they'd tell you to swear them off completely. I haven't read the studies ITT yet but that's how it usually goes.
      Btw why tf do so many people take minox so young? At 21 you have still a good chance of growing a nice beard naturally

      • 2 months ago
        Anonymous

        My cousin and I were the same height for most of our lives except he didn't smoke a copious amount of weed and he was also physically active. He grew another 2 inches at 20 - 23. I was 6'1 by 14 but wasted my youth playing vidya. I was projected to be 6'3. Wish I could go back

        • 2 months ago
          Anonymous

          Then there's a chance, but who knows if it's a big or a small one. 7 months of minoxidil cream on your chin doesn't sound like enough to cut two inches from your growth but still, who knows. The point is that that's how it went and it's pointless to keep thinking about it, 6'1" is a good height and even if you were 5'6" it would be healthier to not give it too much importance

        • 2 months ago
          Anonymous

          >He grew another 2 inches at 20 - 23.
          He literally did not.

          When I saw you saying "grow more" between 20 and 21 I assumed you must have meant grow more muscles, it is insane the amount of people here that think they're in the 0.0000001% of the population that grows any significant amount at all after age 18 never mind 2 inches.

      • 2 months ago
        Anonymous

        >Btw why tf do so many people take minox so young? At 21 you have still a good chance of growing a nice beard naturally
        Minox for beard growth doesn't work the same way it does for hair growth, i.e. you don't have to use it for the rest of your life to keep your gains. So it seems logical to use minox for a high chance of results instead of just hoping that your beard starts growing by itself.

  23. 2 months ago
    Anonymous

    frens, I've taking minox orally (drinking it) for the past 4 months, should I stop ?

    • 2 months ago
      Anonymous

      you'll be taking other things orally when you become a full blown chud

  24. 2 months ago
    Anonymous

    I don't trust basedience, I've been on Minox for over a year and my T levels are at 1060 ng/dL measured not so long ago.

  25. 2 months ago
    Anonymous

    oh wow things chuds use turn you into a woman who knew

  26. 2 months ago
    Anonymous

    Would putting this stuff in my scalp help me grow out my beard? I don't want to put it on my face because it dries the fuck out of your skin on account of the high alcohol content.

    • 2 months ago
      Anonymous

      Use the foam on your face. It takes some time to dry so I'd apply it 1-2 hours before bed.

  27. 2 months ago
    Anonymous

    interesting. i will read this in detail. i haven't had any noticeable side effects from minoxidil. while for me finasteride side effects began literally overnight, so the 5α activity in minoxidil can't be nearly as pronounced

  28. 2 months ago
    Anonymous
    • 2 months ago
      Anonymous

      there's entire channels and subreddits dedicated to min sexual side effects, but noooooo they're all lying!

      • 2 months ago
        Anonymous

        Yes they are. If they aren't they are just suffering from ED not related to minoxidil like 30% of men....

        • 2 months ago
          Anonymous

          >post minoxidil syndrome
          holy shit lmao

          >using a compound which downregulates androgen receptors and 5α-R2 expression can't possible effect male sexual function even though that's exactly how it functions because...IT JUST CAN'T OK?!?
          >FUCKKKK THIS CAN'T BE REAL DUDE I JUST WANNA BE A COOL ALPHA MAN, FUCK I WANNA LOOK IN THE MIRROR AND NOT CRY LIKE A chud

          grow some nuts gay. oh wait, you can't, fin and min destroyed them.

    • 2 months ago
      Anonymous

      >post minoxidil syndrome
      holy shit lmao

  29. 2 months ago
    Anonymous

    It works.

    i was looking like Beetlejuice 2 years ago, now my hair is thick again.

    No sides, nothing... 34yo.

    Why this propaganda campain?

  30. 2 months ago
    Anonymous

    >In addition, a recent studies have showed in a cell model experiment that minoxidil caused a significant downregulation of 5α-reductase type 2 gene expressions compared with untreated control cells.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759057/

    This is from a 2020 clinical review.

    >https://wikiless.org/wiki/5%CE%B1-Reductase_2_deficiency
    >5αR2 is expressed in specific tissues and catalyzes the transformation of testosterone (T) to 5α-dihydrotestosterone (DHT). DHT plays a key role in the process of sexual differentiation in the external genitalia and prostate during development of the male fetus. 5αR2D is a result of impaired 5αR2 activity resulting in decreased DHT levels. This defect results in a spectrum of phenotypes including overt genital ambiguity, female appearing genitalia, hypospadias, penile urethra, and micropenis formation.

    Block 5α-R2 using minoxidil or finasteride at your own risk.

  31. 2 months ago
    Anonymous

    Well Min/Fin has stopped my hairloss, and hasnt prevented the progress of any of my lifts, nor effected my sex drive. So why should I (ME) care.

    Riddle me that geniuses

  32. 2 months ago
    Anonymous

    lmao @ theory nerds who read studies and kvetch about side effects while I roid and use fin and fuck girls

  33. 2 months ago
    Anonymous

    I unironicly don't care anymore. I've been on It and fin for 5 years and I do Testosteron check every 5 months and so and they are either normal or sometimes even high. I guess I'm lucky then.

  34. 2 months ago
    Anonymous

    I refuse to take drugs and I am simply waiting for stem-cell based or similar hair transplant procedures.

    I still have hair for now, but I feel like I'm loosing it. Big bummer, but hair transplant tech has just gotten better over time, tbh. And it's not a requirement to be on any meds pre or post hair transplant, it's just highly recommended, but I plan on telling my doctor to sugmuh balls.

    • 2 months ago
      Anonymous

      >I refuse to take drugs and I am simply waiting for stem-cell based or similar hair transplant procedures.
      here is the thing, anon. Once those miracle procedures becomse available, everybody will hop on these. Thats when those markers (like a head full of hair) will lose its value. Society is a game of limited resources. By taking certain steps, you can try to get ahead of the pack, cheat your genetics, so to speak. Im not necessary saying that minox is that certain step. All Im saying is that Im 5'7, and seriously pushing it, if I lose my hair. This might not mean much but good hair add you 2 inches, as well as soles shoes, which might add up to few more inches compared to the rest of the population

  35. 2 months ago
    Anonymous

    Is this referencing oral or topical?

    • 2 months ago
      Anonymous

      Topical but they have the same effect

  36. 2 months ago
    Anonymous

    This makes ok no sense

    Why this anger about fin and minox? Are you afraid of not finding a man with high T to fill you ass with hot cum? gay

    Shit works, hair is strong and not falling
    My head dont reflect the sun anymore

  37. 2 months ago
    Anonymous

    >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039155/
    i was taking this seriously until in the results section:
    >Regaine 5% minoxidil topical
    >regaine
    lmao, these are the standards of scientific papers. do these people not proofread before submitting a study.

    • 2 months ago
      Anonymous

      It's not a error. Regaine is just the name that Rogain goes by in some markets outside the US. Both products are produced by Johnson & Johnson.

  38. 2 months ago
    Anonymous

    Could you offset this with exogenous testosterone?

  39. 2 months ago
    Anonymous

    >NOOOOOO DON'T TAKE LITERALLY 1 PILL A NIGHT TO NEVER BAAAALD YOU HAVE TO BE BALD LIKE MEEEE NOOOOOOOOOOOO

    been on finn for 3 years, still bang my wife every night. My loads are huge, and my cock is hard.

    AND I STILL HAVE HAIR LOL

    • 2 months ago
      Anonymous

      WTF are those discoloured patches of skin. This isn't a normal baldo.

    • 2 months ago
      Anonymous

      Imagine striving to look like this cunt when you can take minox and have a full head of thick hair.

  40. 2 months ago
    Anonymous

    >https://pubmed.ncbi.nlm.nih.gov/30064598/
    >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039155/

    >both studies performed in vitro
    >both studies consist of basically soaking cells in minoxidil for 16 hours and then describing the results on androgen receptors
    >low i.q incel then extrapolates this to in vivo total systemic testostrone production

    bravo, youve proven how utterly moronic you are

    • 2 months ago
      Anonymous

      The problem with IST and I really don't blame anyone here for it is that none of us actually can determine the quality of a study. Not all scientific studies are the same, there are alot of factors that goes into play when determining if the results of the study can be trusted or not but IST takes a study then goes straight to the results thinking the study itself is valid for just existing.

      • 2 months ago
        Anonymous

        you don't have to be a genius to read the methodology section of a study and determine its validity or relevance

        for this study, its very obvious both groups used to most extreme methodology in order to ''prove'' their hypothesis, which is very common with in vivo stuff

        an actual solid study on this topic would involve control groups, double blind placebo and minox groups, with cellular samples and blood samples taken both pre and post minoxidil treatment being looked at under a microscope for changes.

        but maybe im just giving too much credit to the average IST user

    • 2 months ago
      Anonymous

      kinda like when they make articles about how some substance obliterates cancer cells but the experiment was in vitro an said substance also obliterates normal human cells, a bunch of nothing. Also this

      The problem with IST and I really don't blame anyone here for it is that none of us actually can determine the quality of a study. Not all scientific studies are the same, there are alot of factors that goes into play when determining if the results of the study can be trusted or not but IST takes a study then goes straight to the results thinking the study itself is valid for just existing.

      , I doubt that more than a couple of anons on this board can fully and properly understand the studies posted ITT, and I sure as hell am not one of them

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