Mitochondria dysfunction - How to improve

Ive read that supplements cause as taurine, cysteine, carnitine, alpha lipoic acid are goated for this.
Is there anything else i should consider supplementing? I know there are few nutrient supplements that can help.

Along with this i will do lifting, at times extended fasting and focusing on early sleep and maintaining good sleep pattern

any anons dealt with this before?

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  1. 11 months ago
    Anonymous

    -just- suck wiener dude, that'll wake you up hardcore!

  2. 11 months ago
    Anonymous

    >taurine, cysteine, carnitine, alpha lipoic acid
    All of this is in meat. Sounds like you just need meat.

    • 11 months ago
      Anonymous

      That is true but taurine is found mostly in fresh meat and im a citycel so difficult to find freshly butchered meat. Im not sure about these other ones, whether they fade the longer the meat sits

      • 11 months ago
        Anonymous

        Taurine and carnitine are destroyed by the cooking process. If you are willing to eat your meat raw, you will get a lot more. You could also eat scallops if you can find any, as they are high in taurine

        • 11 months ago
          Anonymous

          Dont listen to rawtards OP

          • 11 months ago
            Anonymous

            What exactly makes someone who eats raw meat a "rawtard"? Why exactly should I burn my meat, destroy it's nutrients, and turn it into goyslop?

            • 11 months ago
              Anonymous

              this is just imo, but because of the risk of parasites and other chemicals not being broken down. and you probably weren't raised by wolves, so i doubt you have the proper microbiome.

              https://i.imgur.com/fCYEk6m.jpg

              Sprint OP.

              HIIT Workouts Turbocharge Our Mitochondria’s Superpowers
              High-intensity interval training enhances mitochondrial bioenergetics.

              https://www.psychologytoday.com/us/blog/the-athletes-way/202112/hiit-workouts-turbocharge-our-mitochondria-s-superpowers

              i like this idea, i've read that it's good for telomere lengths too. surely there is a drawback though?

              NAC is poison. Please don't trust meme studies.

              i don't know about calling it poison but it definitely seems like something to treat yourself with as a therapy rather than take constantly. for example, i've read that it can cause cancers to increase their rate of growth.

              • 11 months ago
                Anonymous

                I have been eating raw meat for 5, nearly 6 years no problem. I think my microbiome is doing just fine. It is natural for humans to eat this way, so a human microbiome should readily adapt to this way of eating.

              • 11 months ago
                Anonymous

                i cooked some steak bleu the other day and it was great didnt get sick or anything

              • 11 months ago
                Anonymous

                i cooked some steak bleu the other day and it was great didnt get sick or anything

                my thinking is that just because you can doesn't mean it's necessarily better for you though. i suppose time will tell if you're committed to it, they do say sear marks are carcinogenic so at least you're avoiding that lol

              • 11 months ago
                Anonymous

                >sear marks are carcinogenic
                i think thats because people cook with unstable industrial oils i.e. seed oils. if youre cooking with more stable saturated animal fats its probably a non issue or at least much less of an issue

              • 11 months ago
                Anonymous

                No, it is not a non issue and it has nothing to do with the cooking oil. The heating process itself is the problem and yes, browing of the meat is inherently carcinogenic.
                https://en.m.wikipedia.org/wiki/Maillard_reaction

              • 11 months ago
                Anonymous

                cancer was much more rare a hundred years ago. people werent eating all raw foods but they werent eating seed oils

              • 11 months ago
                Anonymous

                yeah probably because they ate less cooked meat too. Cooked meat is fricking terrible for you and I understand why it is classed as a carcinogen, it is entirely because of the cooking process

              • 11 months ago
                Anonymous

                its definitely possible but i think seed oils replacing more stable saturated animal fats are the bigger issue

              • 11 months ago
                Anonymous

                well I can't argue with a get like that.
                Anyways, we can agree that saturated fats are great. tbh I eat 1-2 pounds of butter a week, and drink 2 quarts of raw cream a week
                has greatly improved my health

              • 11 months ago
                Anonymous

                Carnitine is good for you its in meat

              • 11 months ago
                Anonymous

                looks like he secretly eats carbs

            • 11 months ago
              Anonymous

              You eat raw meat?

              • 11 months ago
                Anonymous

                Yes. Raw meat, some raw low sugar fruits, raw dairy.

                [...]
                my thinking is that just because you can doesn't mean it's necessarily better for you though. i suppose time will tell if you're committed to it, they do say sear marks are carcinogenic so at least you're avoiding that lol

                I think it is better though. The only concerns people ever have seem to be related to the silly idea of getting sick from parasites, all the while getting sick from the carcinogens generated from cooking as well as the loss of nutrients. Eating it raw prevents it from losing b vitamins, carnosine, carinitine, taurine, prevents the proteins from glycating, etc
                I see no reason to eat cooked meat.

                i cooked some steak bleu the other day and it was great didnt get sick or anything

                Getting sick from raw meat is mostly just a fantasy that people get from watching youtube videos tbh.

            • 11 months ago
              Anonymous

              We absorb more nutrients by cooking it, you're not just gonna get all the nutrients because it's raw. Even vegetables

              • 11 months ago
                Anonymous

                >We absorb more nutrients by cooking it,
                this is just wrong, stop making up stuff.
                You destroy the vitamins and vatioua beneficial compounds like carnoside while also glycating the proteins and oxidizing the fats which destroys you from the inside. Shut the frick up.

              • 11 months ago
                Anonymous

                you cant be helped

              • 11 months ago
                Anonymous

                imagine being this confidently moronic, the world is soo strange.

  3. 11 months ago
    Anonymous

    Sprint OP.

    HIIT Workouts Turbocharge Our Mitochondria’s Superpowers
    High-intensity interval training enhances mitochondrial bioenergetics.

    https://www.psychologytoday.com/us/blog/the-athletes-way/202112/hiit-workouts-turbocharge-our-mitochondria-s-superpowers

    • 11 months ago
      Anonymous

      Interesting thanks anon
      i wonder if weight lifting can produce the same outcomes

      • 11 months ago
        Anonymous

        No problem. Try sprinting + L Citrulline.
        I'm 53, look 35. It works.

        The main purpose of this study is to determine the safest maximum dose of an amino acid, citrulline, which will be used as potential treatment for adult patients with a disorder of energy metabolism called Mitochondrial Encephalomyopathy
        https://namdc.rarediseasesnetwork.org/research-study/7416

        • 11 months ago
          Anonymous

          Lol you're a moronic nitric oxided up Black person!!!

        • 11 months ago
          Anonymous

          NO is terrible for health, look up Ray peat work on it, same thing with GH

          • 11 months ago
            Anonymous

            wtf is NO?

            • 11 months ago
              Anonymous

              dont listen to that tard

            • 11 months ago
              Anonymous

              Nitric oxide

              dont listen to that tard

              >t. Chudcel who thinks consuming massive amounts of NO is healthy
              Enjoy your Inflammation

            • 11 months ago
              Anonymous

              Nitric Oxide, people think it's the primary vasodilator, it's an emergency one that causes vascular leakiness and mitochondrial dysfunction. CO2 produced from proper mitochondrial respiration is the actual primary vasodilator, with a wide range of protective effects.

          • 11 months ago
            Anonymous

            Frick of, you raypeatarts. Ray makes basic mistakes in logic. He can't into logic to be more specific.
            For example, he looked up into pufas. Omg, they are terrible. Yes, they are. Most of the humans were never consuming, escpecially in modern quantities. But he puts omega 3 in the same category, when fish was every day food for humans in the past. British peasants were complaining that they are tired of eating salmon every day. Out body uses omega3 to make the membranes of our cells elastic which prevents their damage and we process omega3 into short chain fatty acids that are antiinflamatory.
            With nitric oxide he looked that there is nitric oxide where is inflamation. But he didn't think that possibly it's not the cause of inflamation, but what our body uses to deal with inflamation. The later is true. It's the same as cholesterol which our body uses to prevent internal bleeding, but doesn't cause arterosclerosis on it's own and is super healthy to consume.
            Frick ray peat and frick his moronic followers!

  4. 11 months ago
    Anonymous

    A combination of Glycine and NAC seems to have a positive effect on mitochondria dysfunction, as well as reversing several biomarkers of aging.

    They are both cheap supplements, so easy to experiment with.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773349/

    • 11 months ago
      Anonymous

      NAC is poison. Please don't trust meme studies.

      • 11 months ago
        Anonymous

        Why is that? I saw one study where it had damaged a heart valve or something

        • 11 months ago
          Anonymous

          Anecdotally it made me hack up my lungs the one time I tried it, felt like I was dying until I stopped. However it seems to disrupt glutamate homeostasis, chelate certain metals in the body, etc.

  5. 11 months ago
    Anonymous

    SS-31

  6. 11 months ago
    Anonymous

    Sugar

  7. 11 months ago
    Anonymous

    CoQ10, Vitamin D, E, B1, B2, B3, B5, B6, B7, K2, Aspirin, T3, Lysine, Taurine, Glycine, Caffiene, Magnesium, Selenium, Zinc, Baking soda.

    Carnitine is carcinogenic garbage due to it inducing excessive lipolysis; the drug Meldonium is considerd a doping drug because it increases endurance and stamina by antagonizing carnitine, forcing the muscles to use sugar as fuel.

    • 11 months ago
      Anonymous

      Carnitine is good for you its in meat

      • 11 months ago
        Anonymous

        It's needed in small amounts and can be made in the body if needed from methionine and lysine, taking a supplement of it is suicidal.

        • 11 months ago
          Anonymous

          Why suicidal?

          • 11 months ago
            Anonymous

            Because intentionally triggering mass lipolysis causes cancer, diabetes, obesity, heart disease, in of itself, what's worse is that most peoples fat stores are mostly PUFA due to it being too toxic to metabolize, lipolysis frees that up and damages organs and mitochondria.

            • 11 months ago
              Anonymous

              so by that logic you should lose fat?

              • 11 months ago
                Anonymous

                Yes and aquire large muscles that can use up the ffa in the blood, allowing organs to safely use sugar for mitochondrial respiration.

              • 11 months ago
                Anonymous

                i meant as in fat loss releasing pufa stored in fat cells

              • 11 months ago
                Anonymous

                You shouldn't promote it, restricting PUFA and eating enough sugar, improving metabolism and excreting the PUFA slowly from baseline lipolysis and glucoronidation so as to not overwhelm the liver and damage organs and energy production capabilities.

    • 11 months ago
      Anonymous

      >aspirin, baking soda, caffeine
      poison

      >everything else
      in meat

      >carnitine
      good for you and lipolysis is good for you frick off troony

      • 11 months ago
        Anonymous

        Lol, what's your body temprature sitting at, have fun being cold and dying young moron.

        • 11 months ago
          Anonymous

          Fricking lol at just repeating everything you read in ray peat forums as gospel dude, shut the frick up, take your toxic t3 pills and candy, and stop peddling this israeli nonsense like it's your religion.

          • 11 months ago
            Anonymous

            >toxic t3 pills
            you can just eat raw ruminant thyroid for the same effect you know, and besides, peat and aajonus have more overlaps when you dig deep enough

            • 11 months ago
              Anonymous

              aajonus promotes a lot of poisonous stuff like eating nuts or eating honey with fats and proteins or eating honey at all, I don't follow that guy.

              • 11 months ago
                Anonymous

                oh you're a carnitard, see tou at raypeatforum.com in a few years

          • 11 months ago
            Anonymous

            Lol the israelites are laughing at you eating your raw testicles and taking cold showers, they know stress will age you rapidly and is the main cause of disease, that's why all kosher food is free of PUFA and the kosher coke is made with cane sugar, they also all take thyroid and live to 100+.

            • 11 months ago
              Anonymous

              I don't take cold showers or eat raw testicles are you assuming I do this? sugar is poison dude, I'm not eating that crap

              • 11 months ago
                Anonymous

                *why are you assuming

              • 11 months ago
                Anonymous

                The body uses sugar for energy. That's why there is blood sugar. Sugar is one of the main energy sources of the cells.

              • 11 months ago
                Anonymous

                I feel better using butter as my main source of energy

                oh you're a carnitard, see tou at raypeatforum.com in a few years

                no I'm not even carnivore. I've been to raypeat forums, everyone there is moronic and prediabetic and looks up to fataases like that georgi guy who flip flops his mind on everything. Every single one of them is in chronically bad health which is worsened by their high augar diets

              • 11 months ago
                Anonymous

                >I feel better using butter as my main source of energy
                as i said, see you in a few years

              • 11 months ago
                Anonymous

                Been doing this for years amd my health has only improved but thanks. I'll see you with an insulin pump in a year

              • 11 months ago
                Anonymous

                my blood glucose is much better after sugarmaxxing, i was almost diabetic when i did low carb, that's how i stumbled upon peat's works

              • 11 months ago
                Anonymous

                Bullshit. My blood glucose never exceeds 80 mg/dl after years of a diet using butter as my main energy source.
                Two more weeks though right?

              • 11 months ago
                Anonymous

                how does dietary sugar improve blood glucose?

              • 11 months ago
                Anonymous

                it doesn't. that guy is a mentally ill and suicidal diabetic

              • 11 months ago
                Anonymous

                sugar helps regulate blood glucose by lowering cortisol and is easily absorbed, and fructose can bypass the fatty acid inhibition, that's why fruits and honey are good for diabetics

                it doesn't. that guy is a mentally ill and suicidal diabetic

                Bullshit. My blood glucose never exceeds 80 mg/dl after years of a diet using butter as my main energy source.
                Two more weeks though right?

                take heed anon, keto works well until it doesn't, every peater i know who was into keto in the past all give the same testimony, they felt really good after doing keto for years and then everything suddenly goes abysmal, trouble sleeping, brainfog, low test, elevated cholesterol, cortisol, and SHBG, no energy, you name it

              • 11 months ago
                Anonymous

                I don't trust anything a peater says because they are all mentally ill geriatrics, and funnily enough every one of them who I've read about trying a "keto diet" flip flopped and didn't actually stay on a keto diet, and ate 100+grams of carbs along with a ton of pufa even when theh "ate keto". the typical "peat" diet causes diabetes and that is reflected in most of its adherants.
                You cannot go wrong with: red meat, animal fat, low sugar fruits/peppers/berries/low harm vegetables like lettuce, cream, eggs.
                This diet CANNOT cause high blood sugar, it is literally impossible unless you are already a diabetic.

              • 11 months ago
                Anonymous

                >This diet CANNOT cause high blood sugar
                yeah it will make you DYEL and impair your glucose tolerance instead, post body

              • 11 months ago
                Anonymous

                The body uses fat and sugar

    • 11 months ago
      Anonymous

      I'm in the field of mitochondrial metabolism and I hate the term mitochondrial dysfunction as it isn't specific at all. Your mitochondria do hundreds of functions that differ between the various tissues in your body. Want to know how to improve your mitochondrial health? Eat a healthy whole foods plant focused diet, exercise regularly (both aerobic and resistance), sleep well, and minimise stress.

      Taking a few of these will improve your health but most of this will just give you expensive piss. The idea that having a CoQ supp will somehow lead to increased energy production is funny, it's not the rate limiting step in the ETC let alone respiration in general.

      • 11 months ago
        Anonymous

        >plant focused diet
        You meant to say you're in the field of regurgitating religious soience dogma.

        • 11 months ago
          Anonymous

          Nah, without doxing myself too hard I've been involved in alot of nutritional based metabolic disorder prevention and treatment with a specific focus on those characterised by mitochondrial dysfunction

          What about OP taurine, ala, taurine, cysteine, carnitine, alpha lipoic acid?

          what will ingesting a bunch of amino acids your body already produces or you consume in suffciient quanities in your diet do? Fricking nothing of course. Is alpha-lipoic acid some magic molecule? No probably not, but if you want some more eat brocolli and tomatoes

          • 11 months ago
            Anonymous

            >Nah
            Yeah actually.

          • 11 months ago
            Anonymous

            taurine is hard to come by without freshly slaughtered meat

            • 11 months ago
              Anonymous

              your body synthesises it in the pancreas via the cysteine sulfinic acid pathway, it is a very abundant molecule.

      • 11 months ago
        Anonymous

        What about OP taurine, ala, taurine, cysteine, carnitine, alpha lipoic acid?

  8. 11 months ago
    Anonymous

    >how to improve mitochondria function
    Do not be fat/lose weight/quit obesity

  9. 11 months ago
    Anonymous

    Zone 2 cardio/Maffetone method running

    Everything else is snake oil, negligible, or mimicking one hundredth of the stimuli provided by aerobic exercise.

    If you want an in depth study, look up Inigo San Millan

    • 11 months ago
      Anonymous

      Lol, aerobic exercise is like speedrunning aging, it literally opposes proper mitochondrial respiration.

      • 11 months ago
        Anonymous

        I don't know man, I think you can literally make everything work or not work.
        Drinking water? You can improve your health or destroy your health.
        Eating meat? It can improve your health or destroy your health
        Aerobic exercise? It can improve your health or destroy your health
        I just don't trust anything anymore seeing as everything is used to push agendas pro or against things. You can literally find studies to prove or disprove ANYTHING. Fairly sure if i searched long enough i could find a study that shows eating shit is the pinacle of health. Nowadays I simply go by feeling to be completely honest.

      • 11 months ago
        Anonymous

        The most peaty exercise is aerobic exercise though, walking

        • 11 months ago
          Anonymous

          Not to the extent of breathlessness lactic acidosis, that's what I mainly think as aerobic exercise.

      • 11 months ago
        Anonymous

        I don't think you know what mito respiration or mitochondrial biogenesis is

        remove seed oils and plant garbage and eat mostly nutritious animal fats
        supplement and biohacking like methylene and red light therapy and hydrogen/magnesium baths

        Source: my ass

        • 11 months ago
          Anonymous

          Nah, without doxing myself too hard I've been involved in alot of nutritional based metabolic disorder prevention and treatment with a specific focus on those characterised by mitochondrial dysfunction
          [...]
          what will ingesting a bunch of amino acids your body already produces or you consume in suffciient quanities in your diet do? Fricking nothing of course. Is alpha-lipoic acid some magic molecule? No probably not, but if you want some more eat brocolli and tomatoes

          >fricking moron s o y jak here, erm extreme stress actually good and even if it wasn't theres nothing you can do because that's pseudoscience

          • 11 months ago
            Anonymous

            >light jogging
            >EXTREME STRESS

            ok fatass

  10. 11 months ago
    Anonymous

    remove seed oils and plant garbage and eat mostly nutritious animal fats
    supplement and biohacking like methylene and red light therapy and hydrogen/magnesium baths

    • 11 months ago
      Anonymous

      >methylene
      methylene blue

  11. 11 months ago
    Anonymous

    Based mitochondrial scientist. Could you explain how obesity hinders mitochondrial respiraton?

    • 11 months ago
      Anonymous

      Likely impaired substrate utilisation (of course impaired glucose uptake, but also it fricks with lipid metabolism) leads to morphological changes with a tendency to a greater amount of fission and mitophagy (lower mito content). There is nothing definitive due to the fact the mitochondria is incredibly complex (for context it is very tissue specific and contains at least 1,138 proteins (if you believe mitocarta v.3-however we are constantly finding new shit in 'plain sight' like in Kienzle et al. 2023 BMC biol. from literally 7 days ago lol). One funny thing about insulin resistance is it leads to a greater coupling of the ETC to OXPHOS (basically more efficient creation of energy (ATP) from food) so fatties burn less calories (for context about 20% of the energy potential we create through chemiosmosis from the ETC is wasted (well it is used to create heat but wasted in the sense it doesn't give us ATP). However, unfortunately for fatties this leads to a greater production of ROS through spurious superoxide formation during the reduction of oxygen.

      • 11 months ago
        Anonymous

        Damn, you're the kind of people that makes me wish knowledge download 'à la Matrix' was a thing. Thank you.

      • 11 months ago
        Anonymous

        in english egghead

  12. 11 months ago
    Anonymous

    huge redpills itt

  13. 11 months ago
    Anonymous

    DONT LISTEN TO THIS PEAT TARD LARPER

    Taurine, ACL, ALA are hard to get enough from diet too boost poor mitochondria

  14. 11 months ago
    Anonymous

    unironically, is coffee good for you? in regards to mitochondrial health.

    also, i welcome any anon to tell me why drinking ~1.5 bottles of wine while walking 10+ miles might not be THAT bad for my mitochondria...

    • 11 months ago
      Anonymous

      Coffee is very good with enough fuel provided for the increased metabolic rate.

  15. 11 months ago
    Anonymous

    Cardio is the best thing to improve the number of mitochondria and their function.

    Specifically zone 2 cardio. That’s essentially getting your heart rate between 120-140 and holding it there for 90 minutes. 3/4 times a week.

    Lifting is not cardio. Ignore people who say it is.

  16. 11 months ago
    Anonymous

    >he didn't take the Ray Peat pill

  17. 11 months ago
    Anonymous

    fasted low intensity cardio, maximizing fat oxidation. you could also combine it with a (high protein) ketogenic diet for even further increased effects.
    taurine is great, but don't take cysteine (and NAC should be used sparingly). I'd also recommend daily 10g glycine. MCT oils can also help increased fat oxidation.
    I've also read some interesting things about methylene blue, but I've never taken it.

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