The Randle Cycle

How credible is the Randle cycle? The idea that I've gathered is:
>carbs inhibit gluconeogenesis from fat
>fat inhibits gluconeogenesis from carbs
Effectively meaning that if you consume carbs + fat at the same time, neither gets properly absorbed and both go to fat storage. Now obviously this can't be absolute, 50cal of fat isn't going to prevent you from absorbing 800cal of carbs as glucose. But, can it prevent you from absorbing a notable portion of it?

I've seen people who propagate the Randle cycle portrayed as fat fucks on IST. Why is this? Is the Randle cycle a keto cope? Is it a carnivore cope? Is it a vegan cope? What is the Randle cycle, IST?

  1. 2 months ago
    Anonymous

    Cause I don’t want to go into it on a Laos sky diving forum, simply put there is more nuance to our metabolism than just the randle cycle but it is true to an extent. However this does not mean that if you eat carbs and fat your body shuts down. Your cells will utilize both that fat and glucose though it may just result in elevated blood glucose for a period of time, but this isn’t that big of a deal. The thing to really take away is eating things very high in fat and sugar are not good, and with result in significantly elevated blood sugar for longer periods of time, but that is pretty common sense at this point. The reason why you see fatties preach the randle cycle is cause it is keto cope and helps people who have unhealthy relationships with food justify their extreme dietary changes.

    TLDR; randle cycle is mostly true, but it’s not that big of a deal so long as you don’t eat shit tons of fat and sugar at once. Ketofatties are always coping.

    • 2 months ago
      Anonymous

      You've got it wrong OP, it doesn't stop both from being taken into your cells for energy properly. What it does is regulate the amount of fat or glucose that is allowed to enter a cell because too much is bad for the cell and can harm it.

      >be person living in developed nation
      >effectively eating standard "american" diet because it has been exported around the globe
      >very high carb and fat content in diet
      >eat 3 meals a day plus snacks
      >every 2-3 hours you dump a load of fat and sugar into your body
      >your cells will allow in the exact right amount of fat and/or glucose and nothing more because that would be bad for them
      >the excess is left in your bloodstream
      >the cells will not unlock the door until interior glucose falls to a specific level
      >it is very likely that before that happens or shortly after, you will eat
      >the randle cycle is ramped up yet again
      The randle cycle is not an on/off switch, it is constantly in action regulating the amount of energy allowed into your cells in the form of carbs and fat. The typical developed nation inhabitant is eating a diet high in both, and so they will most likely have elevated levels of blood sugar far beyond optimal for most of the day. This is not at all "not that big of a deal". It is a very big deal because uncontrolled blood sugar is toxic to every cell in your body through glycation and other factors.
      Sorry but combining carbs and fat in the diet is never a good idea, and it is always damaging to your body unless it is a very small amount of carbs or not a big meal. Likewise enough protein in a large meal with fat can activate the randle cycle, but it does not produce as much glucose as a meal loaded with carbs.

      https://i.imgur.com/eAV3VGg.jpg

      A diet high in saturated fats causes insulin resistance and NAFLD, leading to hyperglycemia and type 2 diabetes. A low fat diet in which the fat is mostly unsaturated reverses this. The Randle Cycle meme is a new cope designed by ketolards to pretend that their high fat diet (HFD) is just as healthy as a low fat diet (it's not). This insulin resistance is what leads to weight gain. The fastest way to induce obesity and NAFLD in a lab is feeding a diet high in saturated fat.

      There is no evidence of this, and several meta-analyses have shown they are not correlated. Also the randle cycle is hard science, not some hypothesis. Stop pedaling lies.
      >https://www.bmj.com/content/351/bmj.h3978
      >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824152/

      • 2 months ago
        Anonymous

        Speak for yourself. I don’t eat a high fat high sugar diet, it’s very easy to avoid the American diet as long as you cook your own food and don’t load on the fat and sugar. my blood glucose has always come back in acceptable ranges regardless of my fasting status, even when I’ve had them first thing in the morning right after I’ve eaten toast with almond butter and a tall glass of milk(tons of fats and carbs). The blood sugar doesn’t stay elevated that long and is negligible as long as you aren’t bombing your system with fatty and sugary food like a maccas hamburger and coke or something like that.

      • 2 months ago
        Anonymous

        >pedaling lies
        I didn't know you could ride a lie like a bicycle. What are you trying to say? also you are wrong, there is lots of evidence out there on pubmed to the contrary. I have already found 5 studies that conclude that you are a gay retard

        • 2 months ago
          Anonymous

          And not a single RCT

    • 2 months ago
      Anonymous

      https://i.imgur.com/KMwGCnr.jpg

      How credible is the Randle cycle? The idea that I've gathered is:
      >carbs inhibit gluconeogenesis from fat
      >fat inhibits gluconeogenesis from carbs
      Effectively meaning that if you consume carbs + fat at the same time, neither gets properly absorbed and both go to fat storage. Now obviously this can't be absolute, 50cal of fat isn't going to prevent you from absorbing 800cal of carbs as glucose. But, can it prevent you from absorbing a notable portion of it?

      I've seen people who propagate the Randle cycle portrayed as fat fucks on IST. Why is this? Is the Randle cycle a keto cope? Is it a carnivore cope? Is it a vegan cope? What is the Randle cycle, IST?

      >it’s not that big of a deal so long as you don’t eat shit tons of fat and sugar at once.

      Yes but that's like 90% of amerishits downing burgers, fries and a large coke before dessert

      • 2 months ago
        Anonymous

        So don’t be like them, problem solved

  2. 2 months ago
    Anonymous

    Gluconeogenesis from fat doesn't happen. The only way to make glucose is by breaking existing muscle tissue because protein is the only one that can be converted to glucose.

    >inb4 eat more protein then
    Futile, there is no pathway in digestion tract to do that. If there were, rabbit starvation wouldn't happen.

    • 2 months ago
      Anonymous
      • 2 months ago
        Anonymous

        Nope. Check your sources and verify.

        • 2 months ago
          Anonymous

          Compelling argument, shame literally everything you said was incorrect so I don't feel any particular need to listen to you.

    • 2 months ago
      Anonymous

      >Is the Randle cycle a keto cope?
      Yes

      >Gluconeogenesis from fat doesn't happen
      Incorrect. Fat is broken down into fatty acids and glycerol. Glycerol is converted into glucose in the liver.

      Randle cycle is a real thing but ketolards misconstrue it deliberately to fit into their delusions about biology. None of THE MUH RANDLE CYCLE posters will ever, EVER post body.

  3. 2 months ago
    Anonymous

    Randle is such a dorky name I wouldn't trust anything associated with it

  4. 2 months ago
    Anonymous

    >Effectively meaning that if you consume carbs + fat at the same time
    >neither gets properly absorbed and both go to fat storage
    this already sounds completely retarded
    so what happens if I eat 1g of fat and 1g of carbs is that gonna yield in more fat gain than eating 10g of fat lmao
    Oh it's a matter of quantity? Well then the whole "randle cycle" or whatever the fuck this bullshit that no one knew about before that bald skinnyfat gay bart kay autist showed up is really doesn't matter does it?
    just fucking irrelevant myopic bullshit for retards to worry about while they eat lard and sugar and drink alcohol constantly losing sight of the big picture like retarded gay moron cattle vermin they are

    if you eat too much you get fat, if you eat too much carbs you get fat, if you eat too much fat you are gonna get fat even faster, and if you eat both fats and carbs to variying ratios to the point where you're eating too many calories you will also get fat
    a 33% fat 33% carb 33% protein diet is gonna be less fattening than a 60% fat 33% protein 7% carbs diet, fat you eat is digested, absorbed and then stored direectly to the point where the fatty acids in your diet can be traced in your adipose tissue.

    TLDR: randle cycle is just ketolard cope, if your LDL-C is too high you WILL get problems I don't care who you are

    • 2 months ago
      Anonymous

      >no one knew about before that bald skinnyfat gay bart kay autist
      Denise Minger spoke about it a while ago, like in the talk where she showed pic related, but the Randle Cycle has definitely gotten popular in the keto/carnivore community lately. Also, Bart is a gay

  5. 2 months ago
    Anonymous

    >idea
    It is a proven mechanism of the human body. The randle cycle is not a theory or a hypothesis. It is observable fact.

    • 2 months ago
      Anonymous

      >It is a proven mechanism of the human body. The randle cycle is not a theory or a hypothesis. It is observable fact.

  6. 2 months ago
    Anonymous

    the more carbs you eat the lower your fat oxidation rates will be, and the more carbs you will burn for energy instead

    how is this so hard for you idiots to understand? You will store the fat you eat regardless of how many carbs you eat, it's just that eating carbs lowers fat usage from your own fat stores for energy.

  7. 2 months ago
    Anonymous

    A diet high in saturated fats causes insulin resistance and NAFLD, leading to hyperglycemia and type 2 diabetes. A low fat diet in which the fat is mostly unsaturated reverses this. The Randle Cycle meme is a new cope designed by ketolards to pretend that their high fat diet (HFD) is just as healthy as a low fat diet (it's not). This insulin resistance is what leads to weight gain. The fastest way to induce obesity and NAFLD in a lab is feeding a diet high in saturated fat.

    • 2 months ago
      Anonymous

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458187/
      https://pubmed.ncbi.nlm.nih.gov/26408952/

      • 2 months ago
        Anonymous

        Now show the one high in saturated fat.

        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976703/#!po=9.74026

        • 2 months ago
          Anonymous

          Try clicking the links and reading sometime.

          • 2 months ago
            Anonymous

            I know you didn't read my study either but
            >muh artifical lab diet doesn't induce obesity because the rats won't eat it
            You're dumb, you're dumb, you're fuckin dumb

            • 2 months ago
              Anonymous

              Retarded cope, just accept the fact that your worldview is an inversion of reality.

            • 2 months ago
              Anonymous

              source for pic?

              • 2 months ago
                Anonymous

                https://healthyeating.sfgate.com/foods-high-linoleic-acid-9573.html

              • 2 months ago
                Anonymous

                Here's another source, just for fun.

                https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650500/

                >Although linoleic acid accounts for ∼88% of the total PUFAs in basedbean oil, the levels in most commonly consumed foods exceed 70%. For example, of all the PUFAs in most meats (beef, chicken, and pork), the contribution of linoleic acid is between 70 and 85% and >80% in eggs.

        • 2 months ago
          Anonymous

          They did a study search and found like 10 studies that claim to have used a higher ratio of saturated fat, but in the first 4 links they give, you cannot find the actual ratio of fats whatsoever.
          Nowhere in this paper exists any hard numbers for what type of fats, what ratio of the types, and what other components there were to the diets.
          Note that all the diets were mixed fat and carbs. None were completely devoid of carbs. This shows absolutely nothing useful for humans except, don't overeat fat and carbs together. Big fucking surprise!

          https://i.imgur.com/6yAPvFt.jpg

          Try clicking the links and reading sometime.

          oopsie someone already BTFO you

          Don’t pay it much kind, just avoid eating high fat and high sugar foods. Pretty common sense

          avoid eating them TOGETHER is the actual accurate response. Not both altogether.

          • 2 months ago
            Anonymous

            No avoid high fat and high sugar. Neither are good for you together or separate.

            • 2 months ago
              Anonymous

              There is no evidence for that claim whatsoever.

              • 2 months ago
                Anonymous

                >evidence
                Lol lmao, “science” said that the vax was 99% effective. Evidence doesn’t mean shit anymore, and there is evidence to support every side, have you seen the carnivore and vegan threads on here both post study after study advocating for both diets for the same reasons. It’s all bullshit, make your own opinions based off of observable facts. Fatties love fat abs love sugar and eat loads of both. Fat in high amounts is bad for you, sugar(not carbs) is just bad for you all together. Eat a moderate amount of fat and as little sugar as possible. It’s that simple.

              • 2 months ago
                Anonymous

                cringe

              • 2 months ago
                Anonymous

                >evidence doesn't mean shit
                >here's why I can't provide evidence
                >here's my opinion
                >it is fact btw
                Alright well I hope no one actually listens to you because this is straight up retarded.

              • 2 months ago
                Anonymous

                Post body, how is telling people to have high fat high sugar diets bad advice?

              • 2 months ago
                Anonymous

                To not have high fat high sugar diets

    • 2 months ago
      Anonymous

      >carb inhibit gluconeogenesis from fat
      in an indirect way sure, if by inhibit you mean high blood glucose and insulin prevents your body from going into starvation mode and from performing gluconeogenesis, but it would prevent ALL GLUCONEOGENESIS, not just specifically from fat.
      >fat inhibits gluconeogenesis
      im not a metabolic expert but this is bullshit. if anything, a fat (or protein) only, low carb diet would put gluconeogenesis on overdrive as your body fights to keep blood glucose high because the brain can only use glucose (and ketones, hence, keto diet) as an energy source (while the rest of the body can use fatty acids). it gets more complicated as mentioned with the fact that obesity and hyperlipidemia will fuck up your fat cells, making them insulin resistant and making them send lipids throughout the body to fuck up every cell's metabolism.
      >if you consume carbs + fats at the same time, neither gets properly absorbed
      that has nothing to do with gluconeogenesis and more to do with digestion and intestinal absorption, also it sounds physiologically bullshit. eating fats does induce your gallbladder and liver to secrete more bile to emulsify the fat, but unless there is a biochemical interaction between glucose and a higher pH fron bile it shouldnt really matter.

      Gluconeogenesis from fat doesn't happen. The only way to make glucose is by breaking existing muscle tissue because protein is the only one that can be converted to glucose.

      >inb4 eat more protein then
      Futile, there is no pathway in digestion tract to do that. If there were, rabbit starvation wouldn't happen.

      fat does convert to glucose. triglyceride is 3 fatty acid chain + glycerol. glycerol can be converted to pyruvate, which is the starting point of gluconeogenesis. fatty acids CANT be turned to glucose but it does turn into acetyl-CoA to make a shitload of ATP (energy for cells) and acetyl-CoA can in turn go into the citric acid cycle for shitloads of more ATP, and ATP helps to run gluconeogenesis because gluconeogenesis requires ATP.

    • 2 months ago
      Anonymous

      that's why dislipidemia is closely correlated with diabetes

  8. 2 months ago
    Anonymous

    So what's a good minimal time difference between fat meals and carb meals if this is true?

    • 2 months ago
      Anonymous

      it isn't true

  9. 2 months ago
    Anonymous

    >The Randle Cycle
    New meme?

    • 2 months ago
      Anonymous

      >reddit randle is at it again

    • 2 months ago
      Anonymous

      First it was nofap. Now it's the Randle Cycle. Get on the nofap and alternating Kempner rice diet and carnivore train or yngmi

    • 2 months ago
      Anonymous

      >new seasonal meme diet just dropped
      Keto is old and busted. The Randle Cycle is the new truth.

  10. 2 months ago
    Anonymous

    im too retarded to understand anything in here

    • 2 months ago
      Anonymous

      Don’t pay it much kind, just avoid eating high fat and high sugar foods. Pretty common sense

    • 2 months ago
      Anonymous

      Welcome

  11. 2 months ago
    Anonymous

    You realize hunter gatherers just ate whatever. Raw eggs, raw liver, boiled bones, didn't matter. They ate fuckin everything. You can eat whatever you want as long as it's not processed shit. If it grows in the ground and isn't poison, or comes from an animal, you're probably fine.

    • 2 months ago
      Anonymous

      Yeah and guess what they didn't collect berries and waited to eat them before they got a nice dead animal
      They either ate berries/plants whatever (carbs) or animals (fats)

      • 2 months ago
        Anonymous

        >they either ate berries/plants whatever (carbs) or animal (fats)
        Are you trying to say that they'd go hunting for couple days to weeks IN THE FUCKING WOODS and not pick berries while hunting?

        • 2 months ago
          Anonymous

          No clearly that is not what he said. He said that if they did pick berries they didn’t wait to eat them until they had meat, meaning they didn’t eat carbs and fats together.

          Realistically berries only grew 1 month a year where our ancestors lived and they would’ve eaten as many of them as they could get their hands on. The small portion of the year that they did eat berries doesn’t matter for their long term health. So even if they did eat them together it doesn’t matter.

          • 2 months ago
            Anonymous

            anyone else get unreasonably happy when they come across wild berries on hikes? I love them

          • 2 months ago
            Anonymous

            >Realistically berries only grew 1 month a year where our ancestors lived
            Wanna know how I know you never go outside?
            T. Scottish anon who can forage ripe wild berries from late July to early October

  12. 2 months ago
    Anonymous

    sounds like pure bullshit to me
    >gluconeogenesis from carbs
    que?

    • 2 months ago
      Anonymous

      maybe he means fructose to glucose in the liver
      not sure

  13. 2 months ago
    Anonymous

    It's probably portrayed as fatties because it's mostly used by ketocultists who unironically say shit like "fruit is poison" while they themselves look like shit such as bald, fat/skinnyfat and old. It's not actually proven either, it's just a hypothesis based off how we do know eating fat will slow down the metabolism of carbs. We do NOT know this is "causing" obesity outside of the normal caloric surplus that fatasses will die on the hill denying they have it.

    • 2 months ago
      Anonymous
      • 2 months ago
        Anonymous

        How does this apply to that anons post, also all the “pro meat doctors” eat carbs and are on roofs guaranteed

  14. 2 months ago
    Anonymous

    Who cares. Why the hell would you eat something none of your ancestors did and think it’s healthy for you? I’ll just sit here with my meat milk and eggs while you guys go bald overthinking everything.

  15. 2 months ago
    Anonymous

    CICO

  16. 2 months ago
    Anonymous

    Some guy on IST said I shouldn't eat steak and asparagus because fat from the steak and carbs from the asparagus are going to combine and make me super fat.

    Is it over for me? I can't even eat meat and vegetables anymore?

    • 2 months ago
      Anonymous

      That's retarded. There are so few digestible carbohydrates in green vegetables they're not worth worrying about. Just don't swig a cola with your steak.

  17. 2 months ago
    Anonymous

    You CAN eat carbs and fats at the same time. You just can't use the same hole. Carbs go in rear.

  18. 2 months ago
    Anonymous

    The thing is that they're not digested at the same rate so it's a literal non issue.

  19. 2 months ago
    Anonymous

    >noooo you can't eat fat and carbs at the same time
    haha pancake go brrrrr

    • 2 months ago
      Anonymous

      You know fat free pancakes exist, right?

      • 2 months ago
        Anonymous

        except i made my pancakes with 10 eggs and lard

  20. 2 months ago
    Anonymous

    >is <insert retarded fad diet book product of the week here> legit?
    No. Just eat normal, idiot

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