What can one do to increase longevity in an affordable way?

What can one do to increase longevity in an affordable way?

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  1. 2 months ago
    Anonymous

    use tret

  2. 2 months ago
    Anonymous

    stop being obese
    stop smoking
    be less stressed
    become higher status

  3. 2 months ago
    Anonymous

    Don’t operate a car

  4. 2 months ago
    Anonymous

    that dude is just using personal branding as a form to sell his "experiment" blueprint subscription and send you some over priced regular ass olive oil that is supposed to stop you from aging, he's created start-up before, he's an expert in marketing and pitching

    • 2 months ago
      Anonymous

      Isn't he already a billionaire

  5. 2 months ago
    Anonymous

    So he lost weight? Wow, what a life hack!

    • 2 months ago
      Anonymous

      I mean, yes?

  6. 2 months ago
    Anonymous

    Don't be vegan

    • 2 months ago
      Anonymous

      ACK

      • 2 months ago
        Anonymous

        >asiatic with plastic surgery
        >asiatic with plastic surgery on gear
        >creep on gear
        >creep on gear

      • 2 months ago
        Anonymous

        Im jealous of Jared Leto's life. He gets front row seats to all of the frickin UFC events. I can see him at every big card

  7. 2 months ago
    Anonymous

    apparently, it's:
    >get hair transplant
    >drop to ~11% bodyfat
    >convince everyone you're "epigenetically 31"

    • 2 months ago
      Anonymous

      don't forget the hair dye

  8. 2 months ago
    Anonymous

    this man takes 60 to 70 pills for breakfast, eats tons of veggies for lunch, and eats nuts in sauce for dinner. he exercises every day, and can absolutely destroy everyone on this board as far as cardio goes even tho hes pushing 50. Hes literally slowed his aging down by maximizing his health as much as he can. He also sleeps 8pm to 5am lol.

    • 2 months ago
      Anonymous

      Brian plz go.

    • 2 months ago
      Anonymous

      Imagine putting all that time in just to “slow down” again. He’s spending all his time seeking more time. Do you understand how stupid and vain that is? Not to mention a waste because in the end you lose and the reaper comes for you regardless.

    • 2 months ago
      Anonymous

      the unimaginable butthurt on this board when he's diagnosed with some obscure cancer or has a heart attack like 60% of other human beings will be hilarious

    • 2 months ago
      Anonymous

      Wair, he's only 50? I thought he was suppose to be 80 or sonething and thats the amazing thing. So he's just a nornal fifty year old who dyes his hair and puts foundation on?

  9. 2 months ago
    Anonymous

    stop making these threads. We get like multiples per day. Dumb zoomers think life is over just because you don't look young when you reach 40.

  10. 2 months ago
    Anonymous

    my homie's cut lookin like a lego figure's hair

  11. 2 months ago
    Anonymous

    >be 46
    >look 56
    This antiageing thing sure is working

    • 2 months ago
      Anonymous

      anyone who wears a crewneck waffle pullover should never be trusted
      >t. crewneck waffle pullover enthusiast

      • 2 months ago
        Anonymous

        are the v neck waffle pullover people ok?

      • 2 months ago
        Anonymous

        >anyone who wears a crewneck waffle pullover should never be trusted
        I agree. Unfortunately the women who trust me never got the memo.

    • 2 months ago
      Anonymous

      He's has so little bodyfat that his hormone production has shut off which requires TRT as a countermeasure. It's very moronic in many ways

  12. 2 months ago
    Anonymous

    dont get fat, engage in regular resistance and cardio activity

    try somewhat to eat healthy

    dont do drugs

  13. 2 months ago
    Anonymous

    i used to think this homie was a wierdo. but after he defeated his cheating prostitute wife, he won my heart. he's now MY weirdo homie

    • 2 months ago
      Anonymous

      that dude is morbidly obese and his parents give him some inflammatory 10k calorie bomb

    • 2 months ago
      Anonymous

      >i used to think this homie was a wierdo. but after he defeated his cheating prostitute wife, he won my heart. he's now MY weirdo homie
      Samesies

    • 2 months ago
      Anonymous

      That's just genetics. Look at his relatives.

  14. 2 months ago
    Anonymous

    He hasn't succeeded in looking younger than a man in his 40s, but it won't be too shabby if he can keep looking like a man in his 40s. I'm skeptical, though.

    • 2 months ago
      Anonymous

      >He hasn't succeeded in looking younger than a man in his 40s, but it won't be too shabby if he can keep looking like a man in his 40s.
      because most of the shit that he peddles is complete bullshit
      TRUE anti-aging is a shortcut to getting cancer
      the anti-aging he's doing is mild life extension, not anti-aging. there's no way to extend your life beyond what you would have died at in a vacuum. he's really just minimizing oxidative and CMR insult on the body.
      wnt, shh, hedgehog, and notch lay out your extremely explicit body plan. if you start genuinely fricking with telomerase, HDAC, and DNMT1 and DNMT3A, you will get cancer.

      he honestly looks like every 50 year old triathlete my parents knew that had a heart attack at like 57

      • 2 months ago
        Anonymous

        Mind explaining why this is the case, I've been a bit of an anti-aging buff myself.

        • 2 months ago
          Anonymous

          basically I'll have to give you a crash course in epigenetics:
          basically your genes are regulated by several things:
          >physical promoter proximity
          this is both longitudinal and 3D. Longitudinal-wise, a closer promoter leads to a more-expressed gene. proteins called CTCF and Cohesins can also "loop" DNA to bring the promoter closer to the gene. if chromatin is tightly packed, it can't be accessed by RNA Misc and thus expressed.
          >DNA methylation
          Methylated DNA in general doesn't get transcribed. post-embryonic DNA methylation is done by DNA methyltransferases (DNMT1 and DNMT3a).
          >histone methylation/acetylation
          Histones are somewhat complicated, but the simple answer is that in general methylation closes the chromatin into a tightly packed configuration, while acetylation opens it up.
          at any given time, histone methyltransferases and deacetylases are opening and closing various locales of the chromatin to stop or start transcription based on the demands of the cell

          Next, your actual body plan is determined by some very important genes and gene groups like wnt (wingless), hedgehog, sonic hedgehog, and notch.
          Basically these genes get turned on and off, and the time, place, and context that they get turned off in determines the fate of the cell. Once the cell has been given a fate, alteration of that fate is extremely oncogenic (literally the first phase of a carcinoma, epithelial-mesenchymal transition or EMT)

          Once your cell has been given a fate, the hayflick limit determines that line's lifespan, which is indirectly related to telomeres. Telomeres are shortened at each division of a cell. Cellular senescence is a planned process because with each division, mutations accumulate. If senescence weren't a factor, a cell would, over a long enough timespan, accumulate enough missense and deletion mutations to experience onco-conversion into cancer.

          • 2 months ago
            Anonymous

            thank you, I have no idea what any of that means

          • 2 months ago
            Anonymous

            >gene groups like wnt (wingless), hedgehog, sonic hedgehog, and notch.
            kek

            Crazy though how morons on this board are trusting schizos like you.

            Truth is, if you actually want to know anything about anti aging, people like Bryan Johnson and David Sinclair are still the best source because they are interacting with actual scientists.

            • 2 months ago
              Anonymous
          • 2 months ago
            Anonymous

            so the question remains: how do we reverse aging
            the answer is, we don't. It's fundamentally nearly impossible without something like an ideal RNA-sized nanomachine in every living cell.

            to reverse aging, you would essentially need to know what the "clean version" of your DNA is, then for every single cell in the body, simultaneously correct all transcription errors ever introduced, while reverting the cells to their original t=0 telomere length at the time of full differentiation.
            If you weren't to do that, you'd get cancer, either immediately or soon after.

            Basically, at the end of the day, interrupting the delicate balance of your personal biology is a terrible idea.

            even the shit that he does for "life extension" is pretty likely to cause him cancer or otherwise frick with his body. I've heard that he takes estrogen, which is a huge problem because for every problem you try to solve with an exogenous compound, there are about 10X as many unrelated signaling cascades that you're fricking with without knowing the effect.
            he's also on metformin, which is just moronic if you're not diabetic since you're fricking with the insulin-glucagon axis for no reason

            https://i.imgur.com/fdXMf4g.jpg

            >gene groups like wnt (wingless), hedgehog, sonic hedgehog, and notch.
            kek

            Crazy though how morons on this board are trusting schizos like you.

            Truth is, if you actually want to know anything about anti aging, people like Bryan Johnson and David Sinclair are still the best source because they are interacting with actual scientists.

            look it up, moron. I've been in medtech and pharma for 10 years with an MS in systems bio. I only stopped publishing when I went industry a year ago.
            those names sound made up but that's just research autists having a giggle

            • 2 months ago
              Anonymous

              Why would he increase chance of cancer when he is putting autophagy into overdrive?

            • 2 months ago
              Anonymous

              also taking extra collagen like he does if you're not collagen deficient is just moronic and a waste of money
              the only thing you can do for your skin is avoid sunlight, stay hydrated, and avoid putting too much shit on it or being stressed in general.
              collagen deposition in the skin ECM is mediated by your fibroblasts. eating more collagen doesn't do anything, it just causes you to shit out more collagen. your skin fibroblasts are by and large inactive unless TGF-B is cleaved from its latency complex by something like a skin wound, and even then, fibroblasts will return the skin to its original condition rather than lay down additional collagen.

              Why would he increase chance of cancer when he is putting autophagy into overdrive?

              that doesn't even mean anything
              What does putting autophagy into overdrive look like?
              autophagy is demand-driven, not something that you can increase unless you're undergoing heightened apoptosis for some reason. And if you've increase apoptosis, you're simply running out the senescence clock on the progenitor cells that are replacing that cell that just underwent apoptosis.
              autophagy is just your dendritic cells and macrophages cleaning up apoptosis products. If it's not happening at an appropriate rate, you've got bigger problems than life extension.

              literally the only way to increase "autophagy" is to
              a) cause more cells to undergo programmed cell death
              b) cause more cells to be directed to commit suicide by CD8+ T Cells

              Neither are particularly beneficial

              • 2 months ago
                Anonymous

                You can cause autophagy through exercise and calorie restriction tho

              • 2 months ago
                Anonymous

                any kind of metabolic insult causes autophagy, but it's not a "good" or "bad" process
                having a rate of autophagy less than another rate of autophagy is neither bad nor good. it's completely agnostic and is more just a descriptive state of the body.
                Look at it this way: if I throw out my food before the expiration date, is that good or bad? or have I just simply thrown out food?

                again, autophagy is just the process of cleaning out unneeded cell products. Your cells do it every day, regardless of your input.
                autophagy is the polar opposite of protein synthesis. if a cell is undergoing autophagy, it is not synthesizing additional proteins. production of autophagocytic lysosomes is directly inhibited by mTOR, which promotes an anabolic growth state. autophagy is promoted by FOXO3, which promotes apoptosis because it is upregulated by oxidative stress.
                If you're expressing FOXO3 and not expressing mTOR, you're in a catabolic state.
                Locally, muscle strain from exercise alone is enough to produce the necessary autophagy of damaged cellular components.

                That makes no sense dude. Autophagy literally extends lifespan in animal models

                >Autophagy literally extends lifespan in animal models
                source

                >for every problem you try to solve with an exogenous compound, there are about 10X as many unrelated signaling cascades that you're fricking with without knowing the effect.

                what's your take on fin/dut?

                risk-benefit ratio doesn't exist for me there
                hair loss doesn't kill you
                it's also not DHT, but sensitivity to DHT in hair cells of the scalp. ablating DHT isn't a good idea just to stop hair loss. Eventually somebody will come up with some kind of competitive scalp androgen receptor antagonist, but until then we're SOL.
                MPB is multifactorial, though. consider an antifungal if you have irritation where your hair loss is occurring

              • 2 months ago
                Anonymous

                >risk-benefit ratio doesn't exist for me there
                >hair loss doesn't kill you
                >it's also not DHT, but sensitivity to DHT in hair cells of the scalp. ablating DHT isn't a good idea just to stop hair loss. Eventually somebody will come up with some kind of competitive scalp androgen receptor antagonist, but until then we're SOL.
                >MPB is multifactorial, though. consider an antifungal if you have irritation where your hair loss is occurring
                I'm just going to ignore everything this guy has to say

              • 2 months ago
                Anonymous

                point out to me where I'm incorrect
                >risk-benefit ratio doesn't exist for me there
                personally I don't want to risk killing my dick or messing with any of the other secondary sex characteristics associated with DHT
                >hair loss doesn't kill you
                it simply doesn't
                >it's also not DHT, but sensitivity to DHT in hair cells of the scalp. ablating DHT isn't a good idea just to stop hair loss. Eventually somebody will come up with some kind of competitive scalp androgen receptor antagonist, but until then we're SOL.
                why does only your head bald? why do people with MPB not drop all of their hair and go completely smooth?
                >MPB is multifactorial, though. consider an antifungal if you have irritation where your hair loss is occurring
                you have no idea how many people end up with hair loss because of malassezia-related psoriatic scalp irritation that looks exactly like MPB

              • 2 months ago
                Anonymous

                >you have no idea how many people end up with hair loss because of malassezia-related psoriatic scalp irritation that looks exactly like MPB
                i am definitely one of these people.

              • 2 months ago
                Anonymous

                Your dick? Bryan Johnson says he has a dick of an 18 year old.

              • 2 months ago
                Anonymous

                >you have no idea how many people end up with hair loss because of malassezia-related psoriatic scalp irritation that looks exactly like MPB

                well frick, I really should have gotten my dandruff/psoriasis under control before hopping on dut. it always stroke me as odd that my dad had 10/10 hair into his late 50s, and to this day has a pretty decent tuft of hair for a 69-y-o

                at least I'm seeing some temple regrowth and my dick hasn't fallen out yet.

              • 2 months ago
                Anonymous

                That makes no sense dude. Autophagy literally extends lifespan in animal models

              • 2 months ago
                Anonymous

                also
                insufficient autophagy is predominantly dictated by a sedentary lifestyle and overfeeding
                putting "autophagy" in "overdrive" is completely meaningless if you're not accumulating damaged cell products for some reason like being a fat frick or never exercising.

            • 2 months ago
              Anonymous

              based effortposter

              thank you, I have no idea what any of that means

              based moron

            • 2 months ago
              Anonymous

              >for every problem you try to solve with an exogenous compound, there are about 10X as many unrelated signaling cascades that you're fricking with without knowing the effect.

              what's your take on fin/dut?

              • 2 months ago
                Anonymous

                nta but frick it, cancer is better than baldness. at least you’ll get sympathy pussy for losing your hair to chemo.

            • 2 months ago
              Anonymous

              You don't reverse aging. But you can not age like an average person. This Bryan is immortality m0gging the poors cause the only consolation the poors have is the rich die too. But the poors can't even afford to take care of themselves. Lol

    • 2 months ago
      Anonymous

      If he finds a way to restore collagen in his face he will actually look younger. Problem is he has taken so much UV damage over decades

  15. 2 months ago
    Anonymous

    what’s funny is he looks exactly the same, just leaner with a hair transplant kek

  16. 2 months ago
    Anonymous

    Fast for 32 hours every sunday.

    10g of Spirulina a day.
    Consume at least 60g of protein a day.

    Don't eat after 5 PM

  17. 2 months ago
    Anonymous

    Another snale oil salesman, thry all are or eventually become, don't listen to anybody's advice there are enough books about everthing just read the fricking wiki

  18. 2 months ago
    Anonymous

    look at his cartilaginous body parts, they will always give away your age. his ears are huge, 70 year old man huge. GH increases as caloric intake decreases, along with thyroid/metabolic function. he's dying.

    • 2 months ago
      Anonymous

      what is the relevance of your photo to your post? it shows the effect of treating hypothyroidism

  19. 2 months ago
    Anonymous

    This dude is a pure grifter, but the ironic part is that he will serve humanity importantly once he croaks 5 years from now and exposes longevity and "health markers" as total scam

  20. 2 months ago
    Anonymous

    Ytpipo
    >spends millions of dollars, works out, takes steroids, chugs 50 pills a day, eats perfectly calibrated diet, does laser therapy and blood transfusion
    >lives up to 80
    >yeees, success
    Some dude in Okinawa
    >eats rice and plays mahjong all day
    >lives to 120

  21. 2 months ago
    Anonymous

    Ew.

  22. 2 months ago
    Anonymous

    how do you look at yourself in the mirror with that narrow box forehead and think to yourself "yeah this looks natural that surgeon did a great job"

    • 2 months ago
      Anonymous

      You think he looks wired, but if you look at the pic on the left you can tell he would be aging worse without his protocol.

      • 2 months ago
        Anonymous

        It's just a shitty transplant. Nobody has a natural hairline like that. Some mexicans have a tiny narrow forehead but it isn't a perfect box like that. Picrel, similarly ridiculous.

        • 2 months ago
          Anonymous

          Jamie fox look like the kind of homie that install handles in his bathtub

        • 2 months ago
          Anonymous

          hes just another

  23. 2 months ago
    Anonymous

    >lncrease longevity in an affordable way

    Don't get fat
    Don't smoke
    Don't drink
    Eat healthy balanced diet
    Avoid seed oils
    Limit exposure to plastics
    Avoid sunlight/use sunblock
    Cardio
    Resistance training (avoid heavy maxes)
    Sleep 7-8 hours
    Supplement vit D and glycine
    Donate blood or plasma regularly to decrease microplastics in body
    Regular visits to doctor

    This is all very affordable for the average person.

    • 2 months ago
      Anonymous

      >Don't get fat
      >Don't smoke
      >Don't drink
      >no fun allowed

      • 2 months ago
        Anonymous

        Being fat is not fun at all. I felt like shit constantly after putting on 30lbs in college. Once I dropped the weight, I felt like I did when I was 18.

  24. 2 months ago
    Anonymous

    ah so that's why he always looks like he's wearing a wig. he "enhanced" his hairline to an uncanny degree. fricking kek

    not fitness btw

  25. 2 months ago
    Anonymous

    I'm honestly starting to think that all this shit is pure placebo. Supplements, therapy, diets, etc. I feel like it's all in your head. if you think something is working it will work and if you think it is harming you you will find evidence of it harming you.

  26. 2 months ago
    Anonymous

    three biggest things you can do that no one will ever do:
    caloric restriction. Try not eating for a day or two every week or so.
    Get out of cities, they significantly reduce your lifespan.
    get a book, learn and do the exercises: qigong teachings of a taoist immortal. English translation of 8 exercises taught by a man who can be proven to have been at least 150+, and according to the 8 generations of families he had fostered actually much older, but still spry and young. Fakes his death after getting too much attention from diplomats and such, returns to the mountains. The people he taught all lived to be 120+, all ended up dying in like mountain climbing accidents. They all said that it was because a) doing these exercises daily, b) caloric restriction, and c) getting out of cities and public life.

    • 2 months ago
      Anonymous

      immortality mogging the poors cause working 50 hour a week is mad stress.

  27. 2 months ago
    Anonymous

    What's with this spam thread like 30 times a day in here?
    Couldn't figure out what israeliery this is, maybe marketing for some shitty anti-age product or something

  28. 2 months ago
    Anonymous

    >lose fat
    >wear make up
    >dye hair
    >try not to die

  29. 2 months ago
    Anonymous

    >before
    >45 year old man
    >after
    >12 year old boy
    yeah fricking right anon. you can't fool me.

  30. 2 months ago
    Christ Is Lord

    rub my product i sell on your face, make sure to use a lot so that its more effective

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